Document Detail


Intestinal water absorption from select carbohydrate solutions in humans.
MedLine Citation:
PMID:  1474096     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eight men positioned a triple-lumen tube in the duodenojejunum. By use of segmental perfusion, 2, 4, 6, or 8% solutions of glucose (111-444 mM), sucrose (55-233 mM), a maltodextrin [17-67 mM, avg. chain length = 7 glucose units (7G)], or a corn syrup solid [40-160 mM, avg. chain length = 3 glucose units (3G)] were perfused at 15 ml/min for 70 min after a 30-min equilibration period. All solutions were made isotonic with NaCl, except 6 and 8% glucose solutions, which were hypertonic. An isotonic NaCl solution was perfused as control. Water absorption (range: 9-15 ml.h-1.cm-1) did not differ for the 2, 4, and 6% CHO solutions but was greater (P < 0.05) than absorption from control (3.0 +/- 2.2 ml.h-1.cm-1). The 8% glucose and 3G solutions reduced (P < 0.05) net water flux compared with their 2, 4, and 6% solutions, but 8% sucrose and 8% 7G solutions promoted water absorption equivalent to lower CHO concentrations. Water absorption was independent of [Na+] in the original solution. In the test segment, 1) Na+ flux correlated with net water flux (r = 0.72, P < 0.01), K+ (r = 0.78, P < 0.01), and [Na+] (r = 0.68, P < 0.001); 2) Na+ absorption occurred at luminal [Na+] as low as 50 mM; 3) glucose transport increased linearly over the luminal concentration range of 40-180 mM; and 4) net water flux was similar over a range of glucose-to-Na+ concentration ratios of 0.4:1 to 3.5:1.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
C V Gisolfi; R W Summers; H P Schedl; T L Bleiler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  73     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-02-01     Completed Date:  1993-02-01     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2142-50     Citation Subset:  IM    
Affiliation:
Department of Exercise Science, University of Iowa College of Liberal Arts, Iowa City.
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MeSH Terms
Descriptor/Qualifier:
Adult
Carbohydrate Metabolism*
Duodenum / metabolism
Glucose / metabolism
Humans
Intestinal Absorption / physiology*
Male
Nephelometry and Turbidimetry
Osmolar Concentration
Polysaccharides / metabolism
Potassium / metabolism
Sodium / metabolism
Solutions
Sucrose / metabolism
Water / metabolism*
Chemical
Reg. No./Substance:
0/Polysaccharides; 0/Solutions; 50-99-7/Glucose; 57-50-1/Sucrose; 7440-09-7/Potassium; 7440-23-5/Sodium; 7732-18-5/Water; 9050-36-6/maltodextrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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