Document Detail


Intestinal vasoregulation in spontaneously hypertensive rats.
MedLine Citation:
PMID:  4083356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intestinal vascular responses to graded reductions in arterial pressure and elevations in venous pressure were measured in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Blood flow and capillary pressure were measured in denervated, autoperfused segments of small intestine. Blood flow, capillary pressure, and total vascular resistance were significantly higher in SHR than WKY at the resting mean arterial pressures. Decrements in arterial pressure led to significant reductions in total vascular resistance in WKY but not in SHR. There was a significant tendency for capillary pressure autoregulation in WKY but not in SHR. Increments in venous pressure did not alter vascular resistance in WKY, yet significantly increased total vascular resistance in SHR. The latter effect was due entirely to a rise in precapillary resistance and is consistent with an enhanced sensitivity of the vasculature to myogenic factors. Intestinal blood flow, measured using 15-micro microspheres, was not significantly different between WKY and SHR in innervated preparations. However, in denervated preparations intestinal blood flow was significantly higher in SHR than WKY, indicating that there is a significant neural component to the increased intestinal vascular resistance in SHR.
Authors:
D N Granger; S L Harper; R J Korthuis; H G Bohlen; P R Kvietys
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  249     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-01-24     Completed Date:  1986-01-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G786-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Capillary Resistance
Cats
Dogs
Hypertension / physiopathology*
Intestines / blood supply*,  physiopathology
Male
Rats
Rats, Inbred SHR
Rats, Inbred Strains
Sympathectomy
Vascular Resistance
Grant Support
ID/Acronym/Agency:
HL-00816/HL/NHLBI NIH HHS; HL-01089/HL/NHLBI NIH HHS; HL-26441/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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