Document Detail

Intestinal pseudo-obstruction following the use of enteral charcoal and sorbitol and mechanical ventilation with papaveretum sedation for theophylline poisoning.
MedLine Citation:
PMID:  1536699     Owner:  NLM     Status:  MEDLINE    
We report 2 cases of intestinal pseudo-obstruction, 1 fatal, which developed following the use of enteral activated charcoal with sorbitol, and mechanical ventilation with papaveretum ('Omnopon') sedation for the treatment of severe theophylline self-poisoning. While mechanical intestinal obstruction may rarely complicate the use of enteral activated charcoal, pseudo-obstruction has not been previously described. Causal mechanisms and prophylaxis are discussed, highlighting a possible interaction between theophylline and papaveretum, and the dangers of multidose enteral charcoal with sorbitol in this context.
P Longdon; A Henderson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Drug safety     Volume:  7     ISSN:  0114-5916     ISO Abbreviation:  Drug Saf     Publication Date:    1992 Jan-Feb
Date Detail:
Created Date:  1992-04-02     Completed Date:  1992-04-02     Revised Date:  2014-11-17    
Medline Journal Info:
Nlm Unique ID:  9002928     Medline TA:  Drug Saf     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  74-7     Citation Subset:  IM    
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MeSH Terms
Charcoal / adverse effects*,  therapeutic use
Drug Interactions
Enteral Nutrition
Intestinal Obstruction / etiology*
Middle Aged
Opium / therapeutic use*
Sorbitol / adverse effects*,  therapeutic use
Theophylline / poisoning*
Ventilators, Mechanical*
Reg. No./Substance:
16291-96-6/Charcoal; 506T60A25R/Sorbitol; 8008-60-4/Opium; C137DTR5RG/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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