Document Detail

Intestinal pseudo-obstruction as a complication of paragangliomas: case report and literature review.
MedLine Citation:
PMID:  24394736     Owner:  NLM     Status:  In-Data-Review    
Intestinal pseudo-obstruction is a rare and relatively unknown complication of phaeochromocytoma÷ paraganglioma (PCC÷PGL). Its pathophysiology can be explained by the hypersecretion of catecholamines, which may reduce the peristaltic activity of the gastrointestinal tract. Clinically, this can result in chronic constipation, intestinal pseudo-obstruction or even intestinal perforation. We conducted a comprehensive literature search and retrieved 34 cases of pseudo-obstruction caused by either benign or malignant PCC÷PGL. We also included a case from our centre that has not been described earlier. We conclude that intestinal pseudo-obstruction is a rare but potentially life-threatening complication of PCC÷PGL. Intravenous administration of phentolamine is the most frequently described treatment when surgical resection of the PCC÷PGL is not feasible.
T E Osinga; M N Kerstens; M M van der Klauw; J J Koornstra; B H R Wolffenbuttel; T P Links; A N A van der Horst-Schrivers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Netherlands journal of medicine     Volume:  71     ISSN:  1872-9061     ISO Abbreviation:  Neth J Med     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-01-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0356133     Medline TA:  Neth J Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  512-7     Citation Subset:  IM    
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