| Intestinal permeability testing in dogs with diet-responsive intestinal disease. | |
| | |
MedLine Citation:
|
PMID: 7474959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Fifteen dogs with signs of small and, or, large bowel disease that responded clinically to an exclusion diet were studied, using differential sugar absorption as an objective parameter of the mucosal response to the diet. Intestinal permeability and function were assessed by determining the urinary excretion ratios of lactulose/rhamnose and xylose/3-O-methylglucose, respectively, following oral administration of a mixture of these four sugars. Five dogs, all retrievers, were tentatively diagnosed as having dietary hypersensitivity, based upon resolution of clinical signs and normalisation of high intestinal permeability following an exclusion diet and recurrence of signs (in four of five dogs) upon challenge with the original diet. The fifth dog did not become symptomatic when challenged, but intestinal permeability increased. The remaining 10 dogs were diagnosed as having food intolerance, based upon clinical improvement on an exclusion diet, relapse on challenge with their original diet, but lack of improvement in intestinal permeability. These findings suggest that a differential sugar absorption test may be useful to determine the reasons for clinical response to exclusion diets. Demonstration of increased intestinal permeability with subsequent normalisation following an exclusion diet may be useful in the diagnosis of dietary hypersensitivity, while persistent abnormalities in intestinal permeability are suggestive of underlying intestinal disease and food intolerance. |
| | |
Authors:
|
H C Rutgers; R M Batt; E J Hall; S H Sørensen; F J Proud |
Related Documents
:
|
20144729 - Dietary protein hydrolysates and free amino acids affect the spatial expression of pept... 19330069 - Intestinal structure and function of broiler chickens on diets supplemented with a synb... 2814039 - Effects of ceruletide on post-operative intestinal atony: a manometric study. 8450069 - Analysis of segmental phosphate absorption in intact rats. a compartmental analysis app... 18270839 - Dietary lipids alter the effect of steroids on the transport of fructose following inte... 12479649 - Potato glycoalkaloids adversely affect intestinal permeability and aggravate inflammato... 10445379 - Caffeine-associated stimuli elicit conditioned responses: an experimental model of the ... 2404049 - Diet intervention methods to reduce fat intake: nutrient and food group composition of ... 2775509 - Dietary treatment as seen by german nephrologists. results of a questionnaire. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of small animal practice Volume: 36 ISSN: 0022-4510 ISO Abbreviation: J Small Anim Pract Publication Date: 1995 Jul |
Date Detail:
|
Created Date: 1995-12-06 Completed Date: 1995-12-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0165053 Medline TA: J Small Anim Pract Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 295-301 Citation Subset: IM |
Affiliation:
|
Department of Small Animal Medicine and Surgery, Royal Veterinary College, North Mymms, Hertfordshire. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Diagnosis, Differential Dog Diseases / diagnosis*, diet therapy, physiopathology Dogs Food Hypersensitivity / diagnosis, veterinary* Glucose / metabolism Intestinal Absorption* Intestinal Diseases / diagnosis, diet therapy, physiopathology, veterinary* |
| Chemical | |
Reg. No./Substance:
|
50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Domestic violence: impact on psychiatric medicine.
Next Document: Measurement of skin hydration in normal dogs and in dogs with atopy or a scaling dermatosis.