| Intestinal permeability, atopic eczema and oral disodium cromoglycate. | |
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MedLine Citation:
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PMID: 1910165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A dual sugar (lactulose-mannitol) absorption test was performed in 19 patients with atopic eczema before and after a 21 day elimination-diet. Moreover L/M test was carried out in 20 controls. The mean value of lactulose-mannitol urinary ratio (L/M) was 0.015 (+/- 0.018 SD) in the group of patients and 0.012 (+/- 0.011 SD) in the control group (p = 0.49). The mean clinical score improved significantly after elimination diet (41,6 +/- 12.9 SD before the diet, 21.7 +/- 10.4 SD after the diet, p less than 0.001) but no significant modification of intestinal permeability was recorded (L/M = 0.015 +/- 0.018 SD before the diet and 0.21 +/- 0.022 SD after the diet, p = 0.38). Using a double blind approach we were not able to demonstrate any significant effect of disodium cromoglycate on the clinical score and intestinal permeability. The connections between food allergy, intestinal permeability and atopic dermatitis have not been understood, but disodium cromoglycate doesn't seem to play a significant role in the treatment of atopic dermatitis nor in the modification of intestinal permeability. |
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Authors:
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A Ventura; S Rinaldi; P Florean; E Agosti |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: La Pediatria medica e chirurgica : Medical and surgical pediatrics Volume: 13 ISSN: 0391-5387 ISO Abbreviation: Pediatr Med Chir Publication Date: 1991 Mar-Apr |
Date Detail:
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Created Date: 1991-10-24 Completed Date: 1991-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100625 Medline TA: Pediatr Med Chir Country: ITALY |
Other Details:
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Languages: eng Pagination: 169-72 Citation Subset: IM |
Affiliation:
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Clinica Pediatrica dell'Universita, Trieste, Italia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adolescent Child Child, Preschool Cromolyn Sodium / administration & dosage* Dermatitis, Atopic / diet therapy, drug therapy*, metabolism Double-Blind Method Female Humans Infant Intestinal Absorption* Lactulose / diagnostic use Male Mannitol / diagnostic use Permeability |
| Chemical | |
Reg. No./Substance:
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15826-37-6/Cromolyn Sodium; 4618-18-2/Lactulose; 69-65-8/Mannitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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