Document Detail

Intestinal pathophysiology in autism.
MedLine Citation:
PMID:  12773694     Owner:  NLM     Status:  MEDLINE    
Autism is a life-long developmental disorder affecting as many as 1 in 500 children. The causes for this profound disorder are largely unknown. Recent research has uncovered pathology in the gastrointestinal tract of autistic children. The pathology, reported to extend from the esophagus to the colon, is described here along with other studies pointing to a connection between diet and the severity of symptoms expressed in autism. The evidence that there is impaired intestinal permeability in autism is reviewed, and various theories are discussed by which a leaky gut could develop. Lastly, some possible ways in which impaired gastrointestinal function might influence brain function are discussed.
John F White
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  228     ISSN:  1535-3702     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-29     Completed Date:  2003-07-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  639-49     Citation Subset:  IM    
Department of Physiology, Emory University, Atlanta, Georgia 30322, USA.
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MeSH Terms
Antigens / immunology
Autistic Disorder / complications*,  physiopathology
Brain / metabolism,  physiopathology
Child, Preschool
Gastrointestinal Diseases / etiology*
Immunotherapy, Active / adverse effects
Intestinal Absorption / physiology
Intestines / immunology,  metabolism,  physiopathology*
Reg. No./Substance:

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