| Intestinal paracellular permeability is not affected in chronic congestive heart failure. | |
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MedLine Citation:
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PMID: 17383229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In chronic heart failure (CHF) it has been proposed that a dysfunction of the gastrointestinal barrier could lead to translocation of endotoxin into the systemic circulation. A secondary inflammatory reaction, observed as increased levels of cytokines, could negatively affect cardiac function. The aims of this paper were therefore to determine whether patients with CHF have a disturbed mucosal barrier and whether it was possible to detect endotoxin in venous blood. METHODS: Nineteen stable patients with CHF (New York Heart Association II-III, EF<or=40% or EF>40% and earlier hospitalisation for heart failure) were investigated. Twenty healthy subjects (HS group) and 25 patients, who were admitted for bone marrow transplantation (BMT group), served as controls. Gastrointestinal permeability was assessed by a (51)Cr-EDTA absorption test. RESULTS: Eleven patients with and eight without peripheral oedema were included. Median age was 76.5 years. Intestinal permeability was 1.82+/-1.96% in the CHF patients and 1.54+/-.59% and 1.9+/-.9% in HS and BMT groups, respectively (p=0.4 and p=0.7, CHF vs HS and BMT, respectively). No difference was found between patients with and without oedema and endotoxins were below the detection limit in all patients. DISCUSSION: This study does not support the hypothesis that patients with CHF have a dysfunctional gastrointestinal barrier, at least as assessed by the (51)Cr-EDTA resorbtion test. |
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Authors:
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M Schaufelberger; I Ekman; E Björnsson; E Kalaitzakis; T Ekman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-26 |
Journal Detail:
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Title: European journal of heart failure Volume: 9 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2007 Jun-Jul |
Date Detail:
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Created Date: 2007-05-14 Completed Date: 2007-08-17 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 574-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Sahlgrenska University Hospital Ostra, Gothenburg, Sweden. maria.schaufelberger@hjl.gu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Bacterial Translocation / physiology Cell Membrane Permeability / physiology* Chromium Radioisotopes / diagnostic use, pharmacokinetics Chronic Disease Edema, Cardiac / physiopathology Edetic Acid / diagnostic use, pharmacokinetics Endotoxins / blood Female Heart Failure / physiopathology* Humans Intestinal Mucosa / physiopathology* Male Middle Aged Prospective Studies Reference Values Ventricular Dysfunction, Left / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Chromium Radioisotopes; 0/Endotoxins; 60-00-4/Edetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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