Document Detail

Intestinal ornithine decarboxylase in short bowel syndrome patients with oral diet.
MedLine Citation:
PMID:  11327746     Owner:  NLM     Status:  MEDLINE    
The major consequence of extensive intestinal resection is loss of absorptive surface area, which results in malabsorption of nutrients; this condition is known as short-bowel syndrome (SBS). Patients with extensive small intestinal resection and colectomy leading to jejunostomy have the most severe SBS. Ornithine decarboxylase (ODC) plays a central role in cell proliferation and in the process of gut adaptation. Polyamine synthesis in crypt cells mediates the action of extracellular growth factors on DNA synthesis and mitotic activity. The aim of this study was to examine ODC expression and activity, diamine oxidase (DAO) activity and polyamine levels in the jejunal mucosa and red blood cells of SBS patients with a jejunostomy. The study group consisted of 6 patients (4 men and 2 women, mean age 55.8+/-9.8 years), who had undergone extensive small bowel resection and colectomy. All patients were maintained on cyclic parenteral nutrition and non-restricted oral nutrition. Two groups of patients operated on for unrelated reasons were included as the jejunum control group (n=6) and the ileum control group (n=13). Non statistical differences were observed in polyamine levels of red blood cells versus the control group (spermidine: 21.0+/-3.6 vs. 17.7+/-1.1 and spermine: 17.1+/-8.6 vs. 13.2+/-1.6 nmol/ml RBC, respectively). No significant decreases in putrescine and spermidine levels were observed between the groups, but spermine levels in SBS jejunum were significantly lower than the controls (P<0.05). In SBS patients a significant decrease in ODC and DAO activity were observed vs jejunum. A significant decrease in ODC-mRNA abundance was found for the SBS patients as compared to the two control groups (P<0.05). These results suggest that in SBS patients with jejunostomy intestinal adaptation may be impaired.
T Segovia-Silvestre; A M Pita; L Vilar; Y Venereo; X Orta; M Farriol
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  20     ISSN:  0261-5614     ISO Abbreviation:  Clin Nutr     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-30     Completed Date:  2001-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Harcourt Publishers Ltd.
Hospital Vall d'Hebron (CIBBIM), Barcelona, Spain.
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MeSH Terms
Adaptation, Biological
Amine Oxidase (Copper-Containing) / metabolism
Case-Control Studies
Cell Division
Intestinal Absorption*
Intestinal Mucosa / enzymology*,  metabolism
Intestine, Small / enzymology,  metabolism,  surgery*
Middle Aged
Ornithine Decarboxylase / genetics,  metabolism*
Parenteral Nutrition
Polyamines / metabolism
RNA, Messenger / metabolism
Short Bowel Syndrome / enzymology*,  physiopathology
Reg. No./Substance:
0/Polyamines; 0/RNA, Messenger; EC Oxidase (Copper-Containing); EC Decarboxylase

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