Document Detail


Intestinal obstruction promotes gut translocation of bacteria.
MedLine Citation:
PMID:  7774478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Translocation of enteric organisms has been implicated as a possible source of sepsis in susceptible patients. Animals studies have suggested that intestinal obstruction promotes bacterial translocation from the gut lumen. The aim of this study was to study the prevalence of bacterial translocation in patients with and without intestinal obstruction. METHODS: Serosal scrapings, mesenteric lymph nodes, and peripheral blood cultures were obtained from 254 patients. Scrapings and nodes were homogenized and incubated aerobically and anaerobically. Full-thickness biopsies underwent villous height analysis. The clinical course was followed for at least six weeks. RESULTS: Bacterial translocation to mesenteric nodes occurred more frequently in patients with large bowel obstruction than in patients without obstruction (14 of 36 patients vs. 16 of 218 patients; P < 0.001). Both aerobic and anaerobic bacteria were found to translocate. The more distal the obstruction, the more likely anaerobic bacteria were to be identified. Translocation of bacteria predisposed to postoperative septic complications (P < 0.05). Villous height was not related to bacterial translocation. CONCLUSIONS: Gut translocation of bacteria is more common in patients with intestinal obstruction, and its association with septic complications appears to be of clinical significance.
Authors:
P M Sagar; J MacFie; P Sedman; J May; B Mancey-Jones; D Johnstone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  38     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-07-12     Completed Date:  1995-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  640-4     Citation Subset:  IM    
Affiliation:
Royal Liverpool University Hospital, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Bacteremia / etiology
Bacteria / growth & development*
Bacterial Infections / etiology,  microbiology,  pathology
Female
Humans
Ileum / microbiology
Intestinal Obstruction / microbiology*,  pathology,  surgery
Intestine, Large
Lymph Nodes / microbiology
Male
Mesentery
Middle Aged
Postoperative Complications / microbiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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