Document Detail


Intestinal mucus trapping in the rapid expulsion of Trichinella spiralis by rats: induction and expression analyzed by quantitative worm recovery.
MedLine Citation:
PMID:  6735469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats were immunized with a Trichinella spiralis infection restricted by chemotherapy to the intestine (the T/M regime) or with a complete infection that resulted in the deposition of muscle larvae. After an oral challenge infection, rapid expulsion could be demonstrated in both groups within 20 min and with 100% recovery of the infectious dose from the stomachs and intestines of infected animals. Immune and nonimmune groups were distinguished by the large numbers of worms in the intestinal lumens of immune rats and large numbers of worms in the intestinal walls in nonimmune rats. Infectious larvae persisted in the stomach lumens for longer in the immune rats. There was no quantitative difference in worm distribution in the intestine during rapid expulsion in rats immunized with the T/M regime or those given a complete infection. However, in the complete infection group 69% of the luminal worms were trapped in mucus; this did not occur during rapid expulsion in rats immunized with the T/M regime. Mucus trapping was observed only when muscle larvae had matured to the infectious stage in muscle (28 days after the primary infection). Complete infection rats challenged at 14 or 21 days did not display significant mucus trapping of larvae in the intestinal lumen. We conclude that (i) mucus trapping is not essential for rapid expulsion and (ii) mucus trapping is produced by systemic exposure to target antigens of the infectious larvae.
Authors:
R G Bell; L S Adams; R W Ogden
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Infection and immunity     Volume:  45     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-08-07     Completed Date:  1984-08-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  267-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Immunity, Innate
Immunization, Passive
Intestinal Mucosa / immunology*
Kinetics
Larva / immunology
Male
Mucus / immunology*
Rats
Rats, Inbred Strains
Trichinella / immunology*
Trichinellosis / immunology*
Grant Support
ID/Acronym/Agency:
AI 17484/AI/NIAID NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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