| Intestinal morphology and transport after ileal resection in rat is modified by dietary fatty acids. | |
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MedLine Citation:
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PMID: 8697672 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors tested the hypothesis that the intestinal morphology and uptake of nutrients after resection of the distal half of the small intestine of rats responds to alterations in the dietary content of saturated (SFA) and polyunsaturated (PUFA) fatty acids. Adult female Sprague-Dawley rats were subjected to a sham operation or to the surgical resection of the distal half of the small intestine, leaving the ileocecal valve intact. The animals were fed chow for 3 weeks, then either chow or isocaloric semisynthetic SFA or PUFA diets for a further 2 weeks. Food consumption, weight gain and jejunal mucosal surface area were unchanged after ileal resection. A microdensitometric autoradiographic technique was used to examine the distribution of 3H-leucine and 3H-lysine along the villus: approximately 70% of uptake occurred in the upper 30% of the enterocytes of the villus in chow-fed rats, and this portion was unchanged by ileal resection. The jejunal uptake of 40 mM of glucose, observed in vitro, was twice as high in animals that had undergone resection and were fed SFA than in those fed PUFA. In summary, (1) there is a separation between the adaptation of intestinal transport function and dynamic/static morphology after ileal resection, and (2) glucose uptake after ileal resection is enhanced by SFA in the diet and is not explained by any changes in the animals' food intake, weight gain or intestinal morphology. |
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Authors:
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M Keelan; C I Cheeseman; M T Clandinin; A B Thomson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and investigative medicine. Médecine clinique et experimentale Volume: 19 ISSN: 0147-958X ISO Abbreviation: Clin Invest Med Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-09-05 Completed Date: 1996-09-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7804071 Medline TA: Clin Invest Med Country: CANADA |
Other Details:
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Languages: eng Pagination: 63-70 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, University of Alberta, Edmonton. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Body Weight Dietary Fats / pharmacology* Fatty Acids / pharmacology Fatty Acids, Unsaturated / pharmacology Female Glucose / metabolism Ileum / metabolism, surgery* Intestinal Absorption* / drug effects Intestinal Mucosa / metabolism Leucine / metabolism Lysine / metabolism Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 50-99-7/Glucose; 56-87-1/Lysine; 61-90-5/Leucine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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