Document Detail

Intestinal microflora and obesity in rats.
MedLine Citation:
PMID:  18661297     Owner:  NLM     Status:  MEDLINE    
The relationship was evaluated between early nutritional experiences, the intestinal microflora and the small intestinal functions in the mechanism of predisposition to obesity development. Male Sprague-Dawley rats were used in which the quantity of nutrition was manipulated from birth to weaning (day 30) by adjusting the number of pups in the nest to 4 small litters (SL) and 10 normal litters (NL) and fed a standard diet from days 30 to 40 of age. After 40 d, the postnatally overfed SL pups became heavier, displayed significantly enhanced adiposity, body mass gain and food intake as well as a significantly higher jejunal alkaline phosphatase and maltase activity than in rats nursed in NL nests. The effect of different early nutrition was also accompanied by the appearance of significantly decreased Bacteroides and significantly increased enterococci and lactobacilli of obese rats than in lean NL rats. The amounts of Bacteroides were negatively correlated with fat pad mass, body mass, body-mass gain and food intake whereas enterococci and lactobacilli were correlated positively with the same parameters. Our results demonstrate that postnatal nutritional experience may represent a predisposing factor influencing ontogeny of small intestine function and development of intestinal microbial communities. The acquired changes and associated alterations in food digestion could be a component of regulatory mechanisms contributing to the development of obesity and its maintenance in later life.
S Mozes; D Bujnáková; Z Sefcíková; V Kmet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-27
Journal Detail:
Title:  Folia microbiologica     Volume:  53     ISSN:  0015-5632     ISO Abbreviation:  Folia Microbiol. (Praha)     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376757     Medline TA:  Folia Microbiol (Praha)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-8     Citation Subset:  IM    
Institute of Animal Physiology, Slovak Academy of Sciences, 040 01 Kosice, Slovakia.
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MeSH Terms
Adipose Tissue / metabolism
Aging / physiology
Animals, Suckling
Bacteroides / growth & development,  isolation & purification
Body Weight
Energy Intake
Enterococcus / growth & development,  isolation & purification
Intestine, Small / enzymology,  microbiology*,  physiopathology
Lactobacillus / growth & development,  isolation & purification
Obesity / microbiology*,  physiopathology*
Rats, Sprague-Dawley / metabolism

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