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Intestinal microbiota and secretory immunoglobulin A in feces of exclusively breast-fed infants with blood-streaked stools.
MedLine Citation:
PMID:  22725615     Owner:  NLM     Status:  Publisher    
Episodes of streaked rectal bleeding are not uncommon in exclusively breast-fed infants less than 6 months of age. Although this rectal bleeding is thought to be associated with food protein-induced proctocolitis, the pathomechanism still remains unclear. The aim of this study was to investigate the intestinal microbiota and secretory immunoglobulin A in feces of breast-fed infants with streaked rectal bleeding. Fecal specimens from 15 full-term infants with streaked rectal bleeding, who had been delivered vaginally and breast-fed, were studied in comparison with similar specimens from 15 breast-fed healthy infants. We subjected the fecal microbiota to phylogenetic analysis and culture for some bacterial species, and examined the presence of fecal secretory immunoglobulin A by enzyme-linked immunosorbent assay. Phylogenetic cluster analysis revealed four major clusters of fecal bacteria, cluster A being found only in healthy infants. The Bacteroides fragilis group was observed more frequently in controls than in patients (p <0.05). The most dominant species belonging to the Enterobacteriaceae group in the controls was Escherichia coli, whereas in the patients Klebsiella was predominant (p <0.05). The levels of secretory immunoglobulin A were shown high in one third of the healthy controls. In conclusion, the pathomechanism of rectal bleeding in exclusively breast-fed infants may be related to the difference in formation of the intestinal flora.
Hideki Kumagai; Shun-Ichi Maisawa; Mamoru Tanaka; Motomichi Takahashi; Yuhei Takasago; Asaka Nishijima; Shuhka Watanabe
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-22
Journal Detail:
Title:  Microbiology and immunology     Volume:  -     ISSN:  1348-0421     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703966     Medline TA:  Microbiol Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Societies and Blackwell Publishing Asia Pty Ltd.
Department of Pediatrics, Hitachiomiya Saiseikai Hospital. Department of Pediatrics, Morioka Children's Hospital. Miyarisan Pharmaceutical Co., Ltd. Nishijima Pediatric Clinic. Watanabe Otolaryngologic and Pediatric Clinic.
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