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Intestinal microbiota and secretory immunoglobulin A in feces of exclusively breast-fed infants with blood-streaked stools.
MedLine Citation:
PMID:  22725615     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Episodes of streaked rectal bleeding are not uncommon in exclusively breast-fed infants less than 6 months of age. Although this rectal bleeding is thought to be associated with food protein-induced proctocolitis, the pathomechanism still remains unclear. The aim of this study was to investigate the intestinal microbiota and secretory immunoglobulin A in feces of breast-fed infants with streaked rectal bleeding. Fecal specimens from 15 full-term infants with streaked rectal bleeding, who had been delivered vaginally and breast-fed, were studied in comparison with similar specimens from 15 breast-fed healthy infants. We subjected the fecal microbiota to phylogenetic analysis and culture for some bacterial species, and examined the presence of fecal secretory immunoglobulin A by enzyme-linked immunosorbent assay. Phylogenetic cluster analysis revealed four major clusters of fecal bacteria, cluster A being found only in healthy infants. The Bacteroides fragilis group was observed more frequently in controls than in patients (p <0.05). The most dominant species belonging to the Enterobacteriaceae group in the controls was Escherichia coli, whereas in the patients Klebsiella was predominant (p <0.05). The levels of secretory immunoglobulin A were shown high in one third of the healthy controls. In conclusion, the pathomechanism of rectal bleeding in exclusively breast-fed infants may be related to the difference in formation of the intestinal flora.
Authors:
Hideki Kumagai; Shun-Ichi Maisawa; Mamoru Tanaka; Motomichi Takahashi; Yuhei Takasago; Asaka Nishijima; Shuhka Watanabe
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-22
Journal Detail:
Title:  Microbiology and immunology     Volume:  -     ISSN:  1348-0421     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7703966     Medline TA:  Microbiol Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Societies and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of Pediatrics, Hitachiomiya Saiseikai Hospital. Department of Pediatrics, Morioka Children's Hospital. Miyarisan Pharmaceutical Co., Ltd. Nishijima Pediatric Clinic. Watanabe Otolaryngologic and Pediatric Clinic.
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