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Intestinal microbiota and fecal transplantation as treatment modality for insulin resistance and type 2 diabetes mellitus.
MedLine Citation:
PMID:  24528224     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The prevalence of obesity and diabetes mellitus type 2 is rapidly increasing around the globe. Recent insights have generated an entirely new perspective that the intestinal microbiota may play a significant role in the development of these metabolic disorders. Alterations in the intestinal microbiota composition promote systemic inflammation that is a hallmark of obesity and subsequent insulin resistance. Thus, it is important to understand the reciprocal relationship between intestinal microbiota composition and metabolic health in order to eventually prevent disease progression. In this respect fecal transplantation studies have implicated that butyrate producing intestinal bacteria are crucial in this process and could thus be considered key players in regulating diverse signalling cascades associated with human glucose and lipid metabolism.
Authors:
S D Udayappan; A V Hartstra; G M Dallinga-Thie; M Nieuwdorp
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-15
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  -     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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This article is protected by copyright. All rights reserved.
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