Document Detail

Intestinal metaplasia is age related in Barrett's esophagus.
MedLine Citation:
PMID:  2252419     Owner:  NLM     Status:  MEDLINE    
The correlation among cellular characteristics of Barrett's esophagus, patient age, and malignant neoplasm is not well documented. This study, which describes a population of 66 patients with Barrett's esophagus spanning 1 to 80 years of age, analyzes the cellular constituents of their lesional tissues by endoscopic biopsy and histochemical and morphometric studies. Goblet cell metaplasia, identified in 50% (n = 14) of pediatric patients, increased significantly to involve 84% (n = 32) of biopsy specimens from adult patients with Barrett's esophagus. This increase was exponential by linear regression analysis (R2 = .64) between the ages of 5 and 29 years. Pediatric patients usually had 25 or less goblet cells per square millimeter of Barrett mucosa with no identifiable epithelial dysplasia or cancer; Nissen fundoplication lessened esophageal inflammation, but the Barrett mucosa persisted. Goblet cell metaplasia maintained a plateau (mean of 57 cells per square millimeter of Barrett mucosa) between the ages of 41 and 80 years. Dysplasia, in situ carcinoma, or invasive carcinoma was found in patients with Barrett's esophagus who were aged 41 years or older. This study demonstrates persistence of Barrett mucosa, increased incidence of goblet cell metaplasia, and predictable changes in goblet cell number with advancing patient age. The relationship between Barrett mucosa and malignant neoplasm remains uncertain, but the goblet cell may serve as a marker of disease chronicity in which setting neoplasia evolves.
S J Qualman; R D Murray; H J McClung; J Lucas
Related Documents :
12235309 - Oropharyngeal swallowing in craniocervical dystonia.
1763639 - Swallowing problems in rheumatoid arthritis.
9374139 - Local injection into mimetic muscles of botulinum toxin a for the treatment of facial l...
18205769 - Barrett's esophagus: a retrospective analysis of 13 years surveillance.
17180629 - Diagnostic sensitivity of contrast swallow for leakage after gastric resection.
2011159 - Dysphagia in patients with the post-polio syndrome.
19776529 - Serum amyloid-a rather than c-reactive protein is a better predictor of mortality in he...
24550559 - Performance of the modified checklist for autism in toddlers in spanish-speaking patients.
3733809 - Transcutaneous oxygen measurement in peripheral occlusive disease. an indicator of woun...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  114     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-01-14     Completed Date:  1991-01-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1236-40     Citation Subset:  AIM; IM    
Department of Pathology, Ohio State University School of Medicine, Columbus.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Aged, 80 and over
Barrett Esophagus / pathology*
Child, Preschool
Epithelium / pathology
Intestinal Mucosa / pathology*
Metaplasia / pathology
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The distribution of enkephalins in human carotid bodies showing cellular proliferation and chronic g...
Next Document:  Normal reticulin level in iliac bone marrow.