Document Detail

Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors.
MedLine Citation:
PMID:  16478679     Owner:  NLM     Status:  MEDLINE    
The anorectic lipid oleoylethanolamide and the orexigenic lipid anandamide both belong to the group of N-acylethanolamines that are generated by the enzyme N-acylphosphatidylethanolamine-hydrolyzing phospholipase D. The levels of the two bioactive lipids were investigated in rat intestines after 24 h of starvation as well as after 1 and 4 h of re-feeding. Total levels of precursor phospholipids and N-acylethanolamines were decreased upon food-deprivation whereas the level of the anandamide precursor molecule was significantly increased. The level of 2-arachidonoyl-glycerol was unchanged as was the activity of N-acyltransferase, N-acylphosphatidylethanolamine-hydrolyzing phospholipase D, and fatty acid amide hydrolase upon starvation and re-feeding. It is concluded that remodeling of the amide-linked fatty acids of N-acylphosphatidylethanolamine is responsible for the opposite effects on levels of anandamide and oleoylethanolamide in intestines of food-deprived rats and not an alternative biochemical route for anandamide synthesis. Furthermore, linoleoylethanolamide, which accounted for more than 50 mol% of the endogenous pool of N-acylethanolamines, was found not to have the same inhibitory effect on food intake, as did oleoylethanolamide following oral administration.
Gitte Petersen; Camilla Sørensen; Patricia C Schmid; Andreas Artmann; Mads Tang-Christensen; Steen H Hansen; Philip Just Larsen; Harald H O Schmid; Harald S Hansen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-26
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1761     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  143-50; discussion 141-2     Citation Subset:  IM    
Department of Pharmacology and Pharmacotherapy, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, 2100 Copenhagen, Denmark.
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MeSH Terms
Arachidonic Acids / metabolism*
Eating / physiology
Food Deprivation / physiology*
Intestines / metabolism*
Oleic Acids / metabolism*
Phospholipids / chemistry,  metabolism
Polyunsaturated Alkamides
Rats, Sprague-Dawley
Reg. No./Substance:
0/Arachidonic Acids; 0/Oleic Acids; 0/Phospholipids; 0/Polyunsaturated Alkamides; 0/oleoylethanolamide; 94421-68-8/anandamide

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