| Intestinal ischemia: treatment by peritoneal lavage with oxygenated perfluorochemical. | |
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MedLine Citation:
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PMID: 3440910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Though the delivery of elemental oxygen to tissues ravaged by anaerobic infection may be useful, little data exists that suggests that such therapy may benefit ischemic tissue. We report the development of a model to test the question that peritoneal lavage with an oxygen containing solution may favorably influence occlusive intestinal ischemia. Adult Sprague-Dawley rats with Nembutal (sodium pentobarbital) anesthesia underwent midline laparotomy; a microvascular clamp was applied to the superior mesenteric artery (SMA); and an inflow and outflow lavage catheter was placed. Treatment groups included control rats undergoing SMA occlusion only without lavage, rats lavaged with albumin during SMA occlusion (medium control), and rats lavaged during SMA occlusion with oxygenated perfluorochemical FC-47 emulsified in albumin (O2-FC-47). The increase in serum L-lactate following occlusion was used as an index of intestinal injury whether the perfusate was maintained at room temperature (28 degrees C) or body temperature (37 degrees C). Beginning with time O, which corresponded to the time of unclamping, subsequent samples were collected at 15, 30, and 60 minutes after a 30-minute SMA occlusion. Sequential lactates in 13 control rats were 4.18, 4.10, 3.88, and 4.52 mmol/L. Albumin lavaged animals had values at 28 degrees C of 2.23, 1.35, 1.8, and 2.44 mmol/L and values at 37 degrees C of 2.22, 1.40, 2.07, and 3.21 mmol/L, respectively. With O2-FC-47 lavage the respective lactates were 1.89, 1.09, 1.32, and 1.44 mmol/L at 28 degrees C and 2.14, 2.19, 2.50, and 2.1 mmol/L at 37 degrees C.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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T F Floyd; A Boroughs; C Garvey; J Dasher; C B Ikeda; H A Sloviter; M M Ziegler |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 22 ISSN: 0022-3468 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1988-04-11 Completed Date: 1988-04-11 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1191-7 Citation Subset: IM |
Affiliation:
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Department of Surgery, Children's Hospital of Philadelphia, PA 19104. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fluorocarbons / administration & dosage, metabolism, therapeutic use* Intestinal Diseases / drug therapy*, metabolism, therapy Intestines / blood supply*, metabolism Irrigation / methods* Ischemia / drug therapy*, metabolism, therapy Male Oxygen / administration & dosage, metabolism, therapeutic use* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Fluorocarbons; 311-89-7/perfluorotributylamine; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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