| Intestinal ischemia/reperfusion injury: defining the role of the gut microbiome. | |
| | |
MedLine Citation:
|
PMID: 20477509 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
Intestinal ischemia/reperfusion (I/R) injury initiates a systemic inflammatory response syndrome with a high associated mortality rate. Early diagnosis is essential for reducing surgical mortality, yet current clinical biomarkers are insufficient. Metabonomics is a novel strategy for studying intestinal I/R, which may be used as part of a systems approach for quantitatively analyzing the intestinal microbiome during gut injury. By deconvolving the mammalian-microbial symbiotic relationship systems biology thus has the potential for personalized risk stratification in patients exposed to intestinal I/R. This review describes the mechanism of intestinal I/R and explores the essential role of the intestinal microbiota in the initiation of systemic inflammatory response syndrome. Furthermore, it analyzes current and future approaches for elucidating the mechanism of this condition. |
| | |
Authors:
|
James Kinross; Oliver Warren; Sonia Basson; Elaine Holmes; David Silk; Ara Darzi; Jeremy K Nicholson |
Related Documents
:
|
4082299 - Brown bowel syndrome. 19816839 - Capsule endoscopy for the small bowel in juvenile polyposis syndrome: a case series. 18076099 - Cerebroretinal microangiopathy with calcifications and cysts (crmcc). 8292879 - Clinical, laboratory and prognostic features of congenital large intestinal motor dysfu... 20152369 - Visceral myopathy causing chronic intestinal pseudoobstruction and intestinal failure i... 19322929 - A case of noonan syndrome and whipple's disease in the same patient. 7619459 - Incomplete reiter's syndrome with focal involvement of the posterior segment. 16894009 - Churg-strauss syndrome in children: a clinical and pathologic review. 9637429 - Multiple schwannomas, multiple nevi, and multiple vaginal leiomyomas: a new dominant sy... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Biomarkers in medicine Volume: 3 ISSN: 1752-0371 ISO Abbreviation: Biomark Med Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2010-05-18 Completed Date: 2010-06-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101312535 Medline TA: Biomark Med Country: England |
Other Details:
|
Languages: eng Pagination: 175-92 Citation Subset: - |
Affiliation:
|
Department of Biomolecular Medicine, SORA, Imperial College London. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic determinants of Type 1 diabetes: immune response genes.
Next Document: Aptamers generated by Cell SELEX for biomarker discovery.