| Intestinal immune system of young rats influenced by cocoa-enriched diet. | |
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MedLine Citation:
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PMID: 18061430 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gut-associated lymphoid tissue (GALT) maintains mucosal homeostasis by counteracting pathogens and inducing a state of nonresponsiveness when it receives signals from food antigens and commensal bacteria. We report for the first time the influence of continuous cocoa consumption on GALT function in rats postweaning. Weaned Wistar rats were fed cocoa-enriched diets (4% or 10% food intake) for 3 weeks. The function of the primary inductive sites of GALT, such as Peyer's patches (PP) and mesenteric lymph nodes (MLN), was evaluated through an analysis of IgA-secretory ability and lymphocyte composition (T, B and natural killer cells), activation (IL-2 secretion and IL-2 receptor alpha expression) and proliferation. T-helper effector cell balance was also established based on cytokine profile (interferon gamma, IL-4 and IL-10) after mitogen activation. A 10% cocoa intake induced significant changes in PP and MLN lymphocyte composition and function, whereas a 4% cocoa diet did not cause significant modifications in either tissues. Cocoa diet strongly reduced secretory IgA (S-IgA) in the intestinal lumen, although IgA's secretory ability was only slightly decreased in PP. In addition, the 10% cocoa diet increased T-cell-antigen receptor gammadelta cell proportion in both lymphoid tissues. Thus, cocoa intake modulates intestinal immune responses in young rats, influencing gammadelta T-cells and S-IgA production. |
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Authors:
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Emma Ramiro-Puig; Francisco J Pérez-Cano; Sara Ramos-Romero; Teresa Pérez-Berezo; Cristina Castellote; Joan Permanyer; Angels Franch; Maria Izquierdo-Pulido; Margarida Castell |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-03 |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 19 ISSN: 0955-2863 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-14 Completed Date: 2008-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 555-65 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight Cacao* Cell Division Cytokines / analysis, secretion Diet* Feces / chemistry Female Immunoglobulin A, Secretory / analysis, metabolism Interleukin-12 / metabolism Intestines / anatomy & histology, immunology* Lymph Nodes / immunology Lymphocyte Activation Lymphocyte Count Lymphoid Tissue / immunology* Male Mesentery Peyer's Patches / immunology Rats Rats, Wistar Weaning |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Immunoglobulin A, Secretory; 187348-17-0/Interleukin-12 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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