| Intestinal immune defences and the inflammatory response in necrotising enterocolitis. | |
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MedLine Citation:
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PMID: 16690363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Necrotising enterocolitis is a devastating neonatal gastrointestinal emergency predominantly affecting low birth weight, premature infants and is accompanied by significant mortality and morbid sequelae. The pathophysiology remains obscure and the management of infants with necrotising enterocolitis has not changed since the recognition of this disease. Necrotising enterocolitis is most likely the clinical culmination of multiple different risk factors interacting with each other to produce bowel injury through a final, common inflammatory pathway. Here, we review intestinal immunity and the specific inflammatory mediators involved in this disease process. |
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Authors:
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Camilia R Martin; W Allan Walker |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-05-11 |
Journal Detail:
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Title: Seminars in fetal & neonatal medicine Volume: 11 ISSN: 1744-165X ISO Abbreviation: - Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-07-18 Completed Date: 2007-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101240003 Medline TA: Semin Fetal Neonatal Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 369-77 Citation Subset: IM |
Affiliation:
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Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Rose-318, Boston, MA 02215, USA. cmartin1@bidmc.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Enterocolitis, Necrotizing
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immunology*,
mortality,
pathology* Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases / immunology*, mortality, pathology* Intestines / immunology* Prevalence Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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