Document Detail


Intestinal immune defences and the inflammatory response in necrotising enterocolitis.
MedLine Citation:
PMID:  16690363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Necrotising enterocolitis is a devastating neonatal gastrointestinal emergency predominantly affecting low birth weight, premature infants and is accompanied by significant mortality and morbid sequelae. The pathophysiology remains obscure and the management of infants with necrotising enterocolitis has not changed since the recognition of this disease. Necrotising enterocolitis is most likely the clinical culmination of multiple different risk factors interacting with each other to produce bowel injury through a final, common inflammatory pathway. Here, we review intestinal immunity and the specific inflammatory mediators involved in this disease process.
Authors:
Camilia R Martin; W Allan Walker
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-05-11
Journal Detail:
Title:  Seminars in fetal & neonatal medicine     Volume:  11     ISSN:  1744-165X     ISO Abbreviation:  -     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-07-18     Completed Date:  2007-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101240003     Medline TA:  Semin Fetal Neonatal Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  369-77     Citation Subset:  IM    
Affiliation:
Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Rose-318, Boston, MA 02215, USA. cmartin1@bidmc.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Enterocolitis, Necrotizing / immunology*,  mortality,  pathology*
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / immunology*,  mortality,  pathology*
Intestines / immunology*
Prevalence
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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