Document Detail


Intestinal imaging of children with acute rotavirus gastroenteritis.
MedLine Citation:
PMID:  15319628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the morphology and motility of the distal small bowel of infants with rotavirus gastroenteritis using non-invasive/non-ionizing imaging technology. METHODS: Prospective, non-randomized observational study of five infants with symptomatic rotavirus infection. Infants were imaged by real-time magnetic resonance imaging (MRI) and ultrasound within 5 days of onset of gastroenteritis symptoms. Imaging studies were repeated in the convalescent period 5 to 9 weeks later. RESULTS: Three of five infants had a significant increase in the ileal wall thickness visualized by ultrasound during acute rotavirus infection compared with convalescence. The number and size of mesenteric lymph nodes visualized by ultrasound appeared similar in the acute and convalescent phases, as did peristaltic activity assessed by MRI. CONCLUSION: Abdominal ultrasound can detect changes in ileal wall thickness in infants with rotavirus infection. These changes may reflect ileal inflammation elicited by viral infection. Such studies may prove useful in evaluating morphologic response to attenuated rotavirus vaccines.
Authors:
Dorsey Bass; Eileen Cordoba; Cornelia Dekker; Anne Schuind; Christopher Cassady
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  39     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-20     Completed Date:  2005-04-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  270-4     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Stanford University, Stanford, California 94305, USA. dorseybass@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Female
Gastroenteritis / pathology,  ultrasonography*,  virology
Humans
Ileum / pathology,  ultrasonography*
Infant
Magnetic Resonance Imaging / methods
Male
Prospective Studies
Rotavirus / isolation & purification
Rotavirus Infections / pathology,  ultrasonography*
Grant Support
ID/Acronym/Agency:
DK56339/DK/NIDDK NIH HHS; DK7762/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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