Document Detail


Intestinal growth-promoting properties of glucagon-like peptide-2 in mice.
MedLine Citation:
PMID:  9252482     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glucagon-like peptide-2 (GLP-2) has been shown to promote intestinal epithelial proliferation. We studied crypt cell proliferation, enterocyte cell death, and feeding behavior in GLP-2-treated mice. GLP-2 had no effect on food consumption [7.7 +/- 0.3 vs. 8.0 +/- 0.4 g/day, saline (control) vs. GLP-2-treated mice, P = not significant]; however, GLP-2 increased the crypt cell proliferation rate (46.0 +/- 1 vs. 57 +/- 5%, control vs. GLP-2, P < 0.01) and decreased the enterocyte apoptotic rate (5.9 +/- 0.7 vs. 2.8 +/- 0.2% apoptotic cells, control vs. GLP-2, P < 0.05) in small bowel (SB) epithelium. GLP-2 induced a significant increase in SB weight (1.3- to 1.75-fold increase over control, P < 0.05 to P < 0.001) in mice 1-24 mo of age. Increased SB weight was maintained after daily administration of GLP-2 to mice for 12 wk, and cessation of GLP-2 administration in older mice led to regression of (increased) SB weight and mucosal height. These observations suggest that GLP-2 regulates both cell proliferation and apoptosis and promotes intestinal growth after both short- and long-term administration in vivo.
Authors:
C H Tsai; M Hill; S L Asa; P L Brubaker; D J Drucker
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  273     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-03     Completed Date:  1997-09-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E77-84     Citation Subset:  IM    
Affiliation:
Department of Medicine, Banting and Best Diabetes Centre, Toronto Hospital, University of Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Biological Markers
Cell Death
Cell Division / drug effects
Colon / growth & development
Feeding Behavior / drug effects*
Female
Gastrointestinal Hormones / pharmacology
Glucagon-Like Peptide 2
Glucagon-Like Peptides
Ileum / growth & development
Intestinal Mucosa / cytology,  drug effects*,  growth & development
Jejunum / growth & development
Male
Mice
Organ Size / drug effects
Peptides / pharmacology*
Proliferating Cell Nuclear Antigen / analysis
Sex Characteristics
Time Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Gastrointestinal Hormones; 0/Glucagon-Like Peptide 2; 0/Peptides; 0/Proliferating Cell Nuclear Antigen; 62340-29-8/Glucagon-Like Peptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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