| Intestinal glutamate metabolism. | |
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MedLine Citation:
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PMID: 10736365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although it is well known that the intestinal tract has a high metabolic rate, the substrates that are used to generate the necessary energy remain poorly established, especially in fed animals. Under fed conditions, the quantification of substrate used by the gut is complicated by the fact that potential oxidative precursors are supplied from both the diet and the arterial circulation. To circumvent this problem, and to approach the question of the compounds used to generate ATP in the gut, we combined measurements of portal nutrient balance with enteral and intravenous infusions of [U-(13)C]substrates. We studied rapidly growing piglets that were consuming diets based on whole-milk proteins. The results revealed that 95% of the dietary glutamate presented to the mucosa was metabolized in first pass and that of this, 50% was metabolized to CO(2). Dietary glucose was oxidized to a very limited extent, and arterial glutamine supplied no >15% of the CO(2) production by the portal-drained viscera. Glutamate was the single largest contributor to intestinal energy generation. The results also suggested that dietary glutamate appeared to be a specific precursor for the biosynthesis of glutathione, arginine and proline by the small intestinal mucosa. These studies imply that dietary glutamate has an important functional role in the gut. Furthermore, these functions are apparently different from those of arterial glutamine, the substrate that has received the most attention. |
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Authors:
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P J Reeds; D G Burrin; B Stoll; F Jahoor |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: The Journal of nutrition Volume: 130 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-04-25 Completed Date: 2000-04-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 978S-82S Citation Subset: IM |
Affiliation:
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U.S. Department of Agriculture/Agricultural Research Service, Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diet Glutamic Acid / administration & dosage, metabolism* Intestinal Mucosa / metabolism Intestines / metabolism* Viscera / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01-HD35679/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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