| Intestinal flora and nutrient absorption after intestinal resection. | |
| | |
MedLine Citation:
|
PMID: 9834391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Intestinal resection results in loss of surface area, motor disruption, and an altered luminal milieu, all of which might influence bacterial growth. Our aim was to determine the effect of extensive intestinal resection in the dog on small intestinal bacterial flora and nutrient absorption. Ten dogs underwent 75% proximal intestinal resection and were killed at either 12 or 40 weeks. Five animals underwent transection alone and were killed at 12 weeks. Ileal aspirates were cultured. Nutritional status and nutrient absorption were measured every 4 weeks. Mean total and anaerobic ileal flora were increased after resection, significantly at 40 weeks. Overall, more cultures from resected animals had more than 5x10(6) total bacteria (6 of 10 vs. 0 of 10, P<0.05) and more than 10(5) anaerobic bacteria (5 of 10 vs. 0 of 10, P<0.05) than unoperated animals. Total but not anaerobic bacteria were increased after transection alone. Ingestion and absorption of carbohydrate decreased but absorption efficiency was maintained. Nitrogen intake decreased but excretion and absorption were unchanged. Fat intake decreased and excretion was unchanged resulting in decreased absorption. Mean intake, excretion, and absorption of nutrients were not influenced by the presence of significant growths of total (>5x10(6)/ml) or anaerobic (>10(5)/ml) bacteria. It was concluded that (1) 75% proximal intestinal resection results in significantly more aerobic and anaerobic bacteria in the ileal remnant; (2) intestinal bacterial content does not correlate with absorption of nutrients; and (3) the colon, and particularly colonic bacteria, may have a more important role in nutrient absorption than luminal flora in the small intestine after resection. |
| | |
Authors:
|
J S Thompson; E M Quigley |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Volume: 1 ISSN: 1091-255X ISO Abbreviation: J. Gastrointest. Surg. Publication Date: 1997 Nov-Dec |
Date Detail:
|
Created Date: 2006-10-19 Completed Date: 2006-11-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9706084 Medline TA: J Gastrointest Surg Country: United States |
Other Details:
|
Languages: eng Pagination: 554-60 Citation Subset: IM |
Affiliation:
|
The Surgical Service, Omaha Veterans Affairs Medical Center, and the Department of Surgery, Section of Gastroenterology, University of Nebraska Medical Center, Omaha, NE 68198-3280, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorption Animals Bacteria / isolation & purification Dogs Food* Intestine, Small / metabolism*, microbiology*, surgery* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Use of an ileal Roux limb to prevent the Roux stasis syndrome.
Next Document: Peptide YY selectively stimulates expression of the colonocytic phenotype.