| Intestinal fermentation modulates postprandial acylcarnitine profile and nitrogen metabolism in a true carnivore: the domestic cat ( Felis catus). | |
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MedLine Citation:
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PMID: 20420757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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N balance and postprandial acylcarnitine profile following intestinal fermentation of oligofructose and inulin were investigated in healthy cats. Two diets were tested in a crossover design: a commercial high-protein cat food supplemented with 4 % DM oligofructose and inulin (spectrum: degree of polymerisation (DP) 2-10: 60 (SE 5) % DM; DP>10: 28 (SE 5) % DM) as high-fermentable fibre (HFF) diet, and the same commercial diet supplemented with 4 % DM cellulose as low-fermentable fibre diet. Eight adult cats were randomly allotted to each of the two diets at intervals of 4 weeks. At the end of each testing period, faeces and urine were collected over a 5-d period, and blood samples were obtained before and at the selected time points postprandially. No differences were found for N intake, N digestibility and faecal N excretion, whereas urinary N excretion was lower when the HFF diet was fed (P = 0.044). N balance was positive in all the cats, and tended to be increased when the HFF diet was fed (P = 0.079). Propionylcarnitine concentrations (P = 0.015) and their area under the curve (AUC) (P = 0.013) were increased when the HFF diet was fed, revealing a more pronounced production and absorption of propionate. Yet, methylmalonylcarnitine concentrations and concurrent AUC were not elevated when the HFF diet was fed, indicating reduced amino acid catabolism. 3-Hydroxy-3-methylglutarylcarnitine concentrations (P = 0.026) and their AUC (P = 0.028) were also reduced when the HFF diet was fed, implying diminished use of branched-chain amino acids as well. In healthy cats, oligofructose and inulin added to a high-protein diet were suggested to reduce postprandial amino acid-induced gluconeogenesis by substitution with propionate. |
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Authors:
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Adronie Verbrugghe; Geert P J Janssens; Eva Meininger; Sylvie Daminet; Koen Piron; Lynn Vanhaecke; Birgitte Wuyts; Johan Buyse; Myriam Hesta |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-27 |
Journal Detail:
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Title: The British journal of nutrition Volume: 104 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 972-9 Citation Subset: IM |
Affiliation:
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Laboratory of Animal Nutrition, Faculty of Veterinary Medicine, Ghent University, Heidestraat 19, B-9820 Merelbeke, Belgium. adronie.verbrugghe@ugent.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Animals Area Under Curve Bacteria / metabolism Carnitine / analogs & derivatives, metabolism* Cats Cross-Over Studies Dietary Proteins / administration & dosage, metabolism* Dietary Supplements Female Fermentation Gluconeogenesis Intestines / metabolism*, microbiology Inulin / metabolism, pharmacology* Male Nitrogen / metabolism* Oligosaccharides / metabolism, pharmacology* Postprandial Period Prebiotics Propionic Acids / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Dietary Proteins; 0/Oligosaccharides; 0/Prebiotics; 0/Propionic Acids; 0/oligofructose; 541-15-1/Carnitine; 7727-37-9/Nitrogen; 79-09-4/propionic acid; 9005-80-5/Inulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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