| Intestinal electric stimulation decreases fat absorption in rats: therapeutic potential for obesity. | |
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MedLine Citation:
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PMID: 15340106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Effective treatment of obesity is based on the restriction of food intake or reduction of absorption or both. The aim of this study was to study whether intestinal electric stimulation (IES) would reduce fat absorption and, thus, would be a potential therapy for obesity. RESEARCH METHODS AND PROCEDURES: Forty rats implanted with serosal electrodes and two jejunal cannulas were divided into 4 groups of 10 each: control (no stimulation), IES with long pulses, IES with trains of short pulses, and IES with trains of short pulses plus treatment with lidocaine. Jejunal transit and fat absorption of a 20-cm jejunal segment (between two cannulas) were investigated during a 45-minute period with or without IES. RESULTS: It was found that both methods of IES accelerated intestinal transit measured by recovery of phenol red and increased the percentage of triglycerides recovered from the distal cannula in comparison with the control group. IES with trains of short pulses was more effective than IES with long pulses in accelerating jejunal transit and reducing fat absorption. Neither of the two IES methods altered the output of fatty acids from the distal cannula. The effects of IES with trains of short pulses on the transit and fat absorption were partially abolished with the treatment of lidocaine. DISCUSSION: It was concluded that IES accelerates intestinal transit and reduces fat absorption, suggesting a therapeutic potential for obesity. IES with trains of short pulses is more effective than IES with long pulses, and its effects are partially mediated by enteric nerves, jejunum. |
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Authors:
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Ying Sun; Jiande Chen |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Obesity research Volume: 12 ISSN: 1071-7323 ISO Abbreviation: Obes. Res. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-09-01 Completed Date: 2004-10-28 Revised Date: 2011-04-27 |
Medline Journal Info:
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Nlm Unique ID: 9305691 Medline TA: Obes Res Country: United States |
Other Details:
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Languages: eng Pagination: 1235-42 Citation Subset: IM |
Affiliation:
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Transneuronix Research and Veterans Research, 301 University Boulevard, 221 Microbiology Building, 1108 The Strand, Galveston, TX 77555-0632, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dietary Fats / pharmacokinetics* Electric Stimulation* Fatty Acids / pharmacokinetics Gastrointestinal Transit Intestinal Absorption* Jejunum / innervation, physiology Obesity / therapy* Rats Triglycerides / pharmacokinetics |
| Grant Support | |
ID/Acronym/Agency:
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1R43-DK063733-01/DK/NIDDK NIH HHS; R43 DK063733-01/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids; 0/Triglycerides |
| Comments/Corrections | |
Comment In:
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Gastroenterology. 2005 May;128(5):1523-4; discussion 1524-5
[PMID:
15887138
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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