| Intestinal dysbiosis in irritable bowel syndrome: etiological factor or epiphenomenon? | |
| | |
MedLine Citation:
|
PMID: 20465494 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
Irritable bowel syndrome (IBS) is a functional disorder of multifactorial origin. Recent interest has been directed to the potential role of intestinal microbiota in the pathophysiology and symptom generation of this syndrome. This hypothesis is supported by the evidence of an infectious trigger in a proportion of patients, the identification of changes in bacterial composition and the detection of antibodies against flagellin, a component of indigenous flora, and by the potential therapeutic modulation of intestinal microbiota with probiotics and nonabsorbable antibiotics in IBS. The study by Lyra et al. assessed fecal microbiota in IBS patients and controls by applying a set of 14 quantitative real-time PCR assays targeting 16S ribosomal RNA gene phylotypes putatively associated with IBS, based on 16S ribosomal RNA gene library sequence analysis. In addition, microbiota composition was investigated over time by applying statistically advanced analyses at three timepoints during 6 months of follow-up. The authors showed that the intestinal flora of patients with diarrhea-predominant IBS diverged significantly not only from controls but also from the other IBS subgroups. The results by Lyra et al. further support the hypothesis that intestinal microbial flora has a role in IBS pathophysiology, and foster the idea that abnormal microbiota may act by triggering local and systemic immune responses linked to symptom generation. Further studies are now needed to clarify the key role of intestinal microbiota (as opposed to a secondary effect) in this common human disease. |
| | |
Authors:
|
Cesare Cremon; Giovanni Carini; Roberto De Giorgio; Vincenzo Stanghellini; Roberto Corinaldesi; Giovanni Barbara |
Related Documents
:
|
15790714 - Candida albicans peritonitis in a patient with felty's syndrome. 2975934 - Parapsoriasis and related conditions. 3704894 - Combined endoscopic and surgical treatment in peutz-jeghers syndrome. 10087494 - Hypereosinophilic syndrome with hodgkin's-like lymphoma in a ferret. 10348514 - Primary sialoangiectasia--a diagnostic pitfall in sjögren's syndrome: case report. 21862354 - An atypical case of lennox-gastaut syndrome not associated with mental retardation: a n... |
Publication Detail:
|
Type: Comment; Journal Article |
Journal Detail:
|
Title: Expert review of molecular diagnostics Volume: 10 ISSN: 1744-8352 ISO Abbreviation: Expert Rev. Mol. Diagn. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-14 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101120777 Medline TA: Expert Rev Mol Diagn Country: England |
Other Details:
|
Languages: eng Pagination: 389-93 Citation Subset: - |
Affiliation:
|
Department of Clinical Medicine, St Orsola Hospital, Via Massarenti 9, Building #5, I-40138 Bologna, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Comments/Corrections | |
Comment On:
|
World J Gastroenterol. 2009 Dec 21;15(47):5936-45
[PMID:
20014457
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Kinetics of the QuantiFERON-TB Gold In-Tube test during treatment of patients with sputum smear-posi...
Next Document: Molecular detection of rhinoviruses.