Document Detail

Intestinal dopaminergic activity in obese and lean Zucker rats: response to high salt intake.
MedLine Citation:
PMID:  12109778     Owner:  NLM     Status:  MEDLINE    
The present study examined intestinal dopaminergic activity and its response to high salt (HS, 1% NaCl over a period of 24 hours) intake in obese (OZR) and lean Zucker rats (LZR). The basal Na+,K+-ATPase activity (nmol Pi/mg protein/min) in the jejunum of OZR was higher than in LZR on normal salt (NS) (OZR-NS = 111.3 +/- 6.0 vs. LZR-NS = 88.0 +/- 8.3). With the increase in salt intake, the basal Na+,K+-ATPase activity significantly increased in both animals (OZR-HS = 145.9 +/- 11.8; LZR-HS = 108.8 +/- 6.7). SKF 38393 (10 nM), a specific D1-like dopamine receptor agonist, inhibited the jejunal Na+,K+-ATPase activity in OZR on HS intake, but failed to inhibit enzyme activity in OZR on NS intake and LZR on NS and HS intakes. The aromatic L-amino acid decarboxylase (AADC) activity in OZR was lower than in LZR on NS intake. The HS intake increased AADC activity in OZR, but not in LZR. During the NS intake the jejunal monoamine oxidase (MAO) activity in OZR was similar to that in LZR. The HS intake significantly decreased MAO activity in both OZR and LZR. The jejunal COMT activity in OZR was higher than in LZR on NS intake. The HS intake reduced COMT activity in OZR but not LZR. It is concluded that inhibition of jejunal Na+,K+-ATPase activity through D1 dopamine receptors is dependent on salt intake in OZR, whereas in LZR, the enzyme failed to respond to the activation of D1 dopamine receptors irrespective of their salt intake.
V A Lucas-Teixeira; T Hussain; P Serrão; P Soares-da-Silva; M F Lokhandwala
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  24     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-11     Completed Date:  2003-01-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  383-96     Citation Subset:  IM    
Institute of Pharmacology and Therapeutics, Faculty of Medicine, Porto, Portugal.
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MeSH Terms
Aromatic-L-Amino-Acid Decarboxylases / metabolism
Catechol O-Methyltransferase / metabolism
Diabetic Nephropathies / metabolism
Dopamine / metabolism*
Enzyme Activation / drug effects,  physiology
Hyperglycemia / metabolism
Hypertension, Renal / metabolism*
Jejunum / drug effects,  enzymology*
Levodopa / metabolism
Monoamine Oxidase / metabolism
Obesity / metabolism*
Rats, Zucker
Sodium Chloride, Dietary / pharmacology*
Sodium-Potassium-Exchanging ATPase / metabolism
Grant Support
Reg. No./Substance:
0/Levodopa; 0/Sodium Chloride, Dietary; EC Oxidase; EC O-Methyltransferase; EC ATPase; EC Decarboxylases

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