Document Detail


Intestinal distension test, a method for evaluating intermittent visceral pain in the rabbit.
MedLine Citation:
PMID:  3412112     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Behavioural response to intestinal distension was studied in 12 female New Zealand albino rabbits under various conditions. On increasing intraluminal pressures, the rabbits elicited uniform behavioural responses within discrete pressure ranges, notably a sudden pelvic withdrawal at 30-50 mmHg. The pressure provoking pelvic withdrawal was chosen as the test parameter and proved to be individually reproducible, irrespective of fasting/non-fasting or the time of day and with no signs of adaptation in six days consecutive measurements. Morphine modified the pressure response in a dose-dependent manner, whereas isotonic saline or pentobarbital had no effect. In conclusion, the intestinal distension test is reproducible and mimicks intermittent visceral pain in the rabbit. This allows for paired observations in small animal populations with a minimum of discomfort to the animals, which offers a major advantage when comparing with the existing visceral pain tests.
Authors:
F M Jensen; J B Madsen; C V Ringsted; A Christensen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  43     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1988  
Date Detail:
Created Date:  1988-10-11     Completed Date:  1988-10-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  747-54     Citation Subset:  IM    
Affiliation:
University of Copenhagen, Pain Clinic, Finseninstituttet/Rigshospitalet, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Fasting
Female
Intestines / physiology*
Methods
Morphine / pharmacology
Movement
Pain*
Pressure
Rabbits
Chemical
Reg. No./Substance:
57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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