| Intestinal digestion, absorption, and transport of structured triglycerides and cholesterol in rats. | |
| | |
MedLine Citation:
|
PMID: 7733283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We compared the intestinal absorption of trilinolein (1,2,3-tri-[1-14C]linoleyl-sn-glycerol) with two different structured triglycerides containing one linoleic acid (C18:2) and two octanoic acids (C8:0), 1,3-dioctanoyl-2-[1-14C]linoleyl-sn-glycerol (2-linoleate) and 1,2-di[1-14C]octanoyl-3-linoleyl-sn-glycerol (1,2-octanoate), respectively. Lymphatic radioactive lipid output of 2-linoleate resembled that of trilinolein rats but remained significantly lower during the lipid infusion. Radioactive lipid was recovered along the entire small intestinal lumen, with a significantly higher amount of [14C]lipid recovered in the lower small intestine and cecum in the 2-linoleate group. Delayed uptake of radioactive 2-linoleate was not due to poor digestion. In contrast, 1,2-octanoate was efficiently digested, and both the free fatty acid (FFA) and the monoacylglycerol (MG) containing octanoate were rapidly absorbed. Irrespective of its position on the triglyceride molecule, 14C-labeled octanoate was poorly transported into lymph. In addition, intestinal luminal and mucosal recovery of [14C]octanoate was significantly lower in the 1,2-octanoate group compared with [14C]linoleate recovery in the 2-linoleate or trilinolein groups. Total recovery of infused radioactive lipid was significantly less in the 1,2-octanoate group than in the 2-linoleate or trilinolein groups. Thus radioactive octanoate in the form of FFA or 2-MG was rapidly absorbed and transported via the portal vein. The infusion of either 2-linoleate or 1,2-octanoate did not affect the absorption and lymphatic transport of cholesterol compared with trilinolein. In summary, the type of the fatty acid on the structured triglyceride molecule affects its digestion, absorption, and lymphatic transport. Structured triglycerides containing octanoic acid in the 1- and 3-positions and linoleic acid in the 2-position may not be advantageous to use as a sole source of dietary lipid, but should be supplemented with long-chain triglycerides. |
| | |
Authors:
|
P Tso; M D Karlstad; B R Bistrian; S J DeMichele |
Related Documents
:
|
3370303 - On the absorption of clavulanic acid. 2293213 - In vitro skin absorption and metabolism of benzoic acid, p-aminobenzoic acid, and benzo... 17647223 - Design of bioinspired polymeric materials based on poly(d,l-lactic acid) modifications ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 268 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1995 Apr |
Date Detail:
|
Created Date: 1995-06-01 Completed Date: 1995-06-01 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: G568-77 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Louisiana State University Medical Center, Shreveport 71130, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorption Animals Biological Transport Cholesterol / metabolism* Digestion* Fatty Acids / metabolism Intestinal Mucosa / metabolism Intestines / metabolism* Lipid Metabolism Liver / metabolism Lymph / physiology Male Phospholipids / metabolism Rats Rats, Sprague-Dawley Triglycerides / chemistry, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
DK-32288/DK/NIDDK NIH HHS; DK-40252/DK/NIDDK NIH HHS; DK-43785/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids; 0/Phospholipids; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Medullary TRH is involved in gastric protection induced by low dose of kainic acid into the raphe pa...
Next Document: Regulation of system y+ arginine transport capacity in differentiating human intestinal Caco-2 cells...