| Intestinal damage in gastroschisis is independent of the size of the abdominal defect. | |
| | |
MedLine Citation:
|
PMID: 11315267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The intestinal damage in gastroschisis (GS) has been attributed to a narrow abdominal wall defect (AWD), among other causes, but this causal effect is difficult to prove in humans. The present experimental study was done to ascertain the damaging effect of clinically extrapolable mild and moderate constriction at the AWD on the intestine of fetuses with GS. AWDs of two different sizes were carried out in the fetal rabbit model: small-ring GS (1.5x bowel diameter, SRG) and large-ring GS (3x bowel diameter, LRG); a group of unoperated littermates served as controls. Fetal body weight, intestinal length and weight, bowel diameter and wall thickness, and histology were checked 7 days later. No statistical difference was found in body weight and bowel diameter among the groups. Intestinal length, weight, and wall thickness were significantly different in the GS groups compared to the controls, but no difference was found between the GS groups. Histology did not show venous stasis, ischemic lesions, or differences in the degree of edema between groups SRG and LRG. Mesothelial hyperplasia was seen in both GS groups. The intestinal changes in length, weight, diameter, wall thickness, and histology in GS should thus not be attributed to the diameter of the AWD. |
| | |
Authors:
|
A Albert; M A Sancho; V Juliá; F Díaz; J A Bombí; L Morales |
Related Documents
:
|
11911117 - Locally and systemically active glucocorticosteroids modify intestinal absorption of li... 14569477 - Effects of hepatectomy and arginine enriched diet on colonic mucosa originated inflamma... 9187547 - Influence of the gut microflora and of biliary constituents on morphological changes in... 8601377 - Jejunal brake: inhibition of intestinal transit by fat in the proximal small intestine. 1732477 - Adipose tissue lipogenesis and fat deposition in leaner broiler chickens. 22119637 - Conversion from enzyme-inducing antiepileptic drugs to topiramate: effects on lipids an... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Pediatric surgery international Volume: 17 ISSN: 0179-0358 ISO Abbreviation: Pediatr. Surg. Int. Publication Date: 2001 Mar |
Date Detail:
|
Created Date: 2001-04-23 Completed Date: 2001-08-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8609169 Medline TA: Pediatr Surg Int Country: Germany |
Other Details:
|
Languages: eng Pagination: 116-9 Citation Subset: IM |
Affiliation:
|
Division of Pediatric Surgery, Unitat Integrada Hospital Sant Joan de Déu-Hospital Clinic, Pg. Sant Joan de Déu 2, 08950 Esplugues de Llobregat, Barcelona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abdominal Muscles
/
pathology Animals Disease Models, Animal Female Gastroschisis / pathology* Gestational Age Humans Infant, Newborn Intestinal Obstruction / pathology* Intestines / blood supply*, pathology Ischemia / pathology* Male Pregnancy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diagnostic dilemmas in abdominal tuberculosis in children.
Next Document: Intra-operative pulse oximetry can help determine intestinal viability.