Document Detail

Intestinal calcium absorption and bone morphology in magnesium deficient chicks.
MedLine Citation:
PMID:  455995     Owner:  NLM     Status:  MEDLINE    
Calcium absorption was measured by 47Ca disappearance from ligated duodenal loops and 47Ca uptake by tibiae in chicks fed diets containing one of four levels of Mg for two weeks. The diets, otherwise identical, contained 88 (group 1), 150 (group 2), 200 (group 3) and 1000 (group 4) ppm Mg. There were no statistically significant differences in 47Ca absorption. Mucosal CaBP and intestinal alkaline phosphatase were slightly, but not significantly, elevated in the Mg depleted chicks in groups 1 and 2 compared to groups 3 and 4. Microscopic examination of the tibiae showed marked alterations in morphology in chicks fed the 88 ppm Mg diet. The thickness of the epiphyseal plate was reduced, and the morphologic signs of osteolysis and chondrolysis, normally observed in the metaphysis, appeared to be absent. The mid-diaphysis was thickened and showed marked reduction in both osteoblast and osteocytie activity. Blood calcium levels were significantly reduced in the Mg deficient chicks. It was concluded that Mg depletion in chicks altered Ca homeostasis primarily by changing bone structure and function.
H F Chou; R Schwartz; L Krook; R H Wasserman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Cornell veterinarian     Volume:  69     ISSN:  0010-8901     ISO Abbreviation:  Cornell Vet     Publication Date:  1979 Jan 
Date Detail:
Created Date:  1979-09-25     Completed Date:  1979-09-25     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0074245     Medline TA:  Cornell Vet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  88-103     Citation Subset:  IM    
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MeSH Terms
Alkaline Phosphatase / metabolism
Calcium, Dietary / metabolism*
Duodenum / enzymology,  metabolism
Intestinal Absorption*
Magnesium Deficiency / metabolism,  veterinary*
Parathyroid Glands / pathology
Poultry Diseases / metabolism*,  pathology
Tibia / metabolism,  pathology*
Reg. No./Substance:
0/Calcium, Dietary; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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