| Intestinal bile acid physiology and pathophysiology. | |
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MedLine Citation:
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PMID: 18837078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bile acids (BAs) have a long established role in fat digestion in the intestine by acting as tensioactives, due to their amphipatic characteristics. BAs are reabsorbed very efficiently by the intestinal epithelium and recycled back to the liver via transport mechanisms that have been largely elucidated. The transport and synthesis of BAs are tightly regulated in part by specific plasma membrane receptors and nuclear receptors. In addition to their primary effect, BAs have been claimed to play a role in gastrointestinal cancer, intestinal inflammation and intestinal ionic transport. BAs are not equivalent in any of these biological activities, and structural requirements have been generally identified. In particular, some BAs may be useful for cancer chemoprevention and perhaps in inflammatory bowel disease, although further research is necessary in this field. This review covers the most recent developments in these aspects of BA intestinal biology. |
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Authors:
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Olga Martinez-Augustin; Fermin Sanchez de Medina |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 14 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-06 Completed Date: 2009-04-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 5630-40 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Granada, Granada 18071, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Acids and Salts / metabolism*, therapeutic use Carrier Proteins / metabolism Colorectal Neoplasms / metabolism*, pathology Enteritis / metabolism*, pathology Enterohepatic Circulation Epithelial Cells / metabolism Humans Intestinal Absorption Intestines / metabolism*, pathology Ion Transport Membrane Glycoproteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Carrier Proteins; 0/Membrane Glycoproteins; 0/bile acid binding proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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