Document Detail

Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense.
MedLine Citation:
PMID:  22095436     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Compromised Paneth cell antimicrobial host defense seems to predispose to BT in experimental cirrhosis. Understanding this liver-gut axis including the underlying mechanisms could help us to find new treatment avenues.
Zora Teltschik; Reiner Wiest; Julia Beisner; Sabine Nuding; Claudia Hofmann; Juergen Schoelmerich; Charles L Bevins; Eduard F Stange; Jan Wehkamp
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Publication Detail:
Type:  Journal Article     Date:  2012-02-15
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  55     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-30     Completed Date:  2012-05-22     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1154-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Association for the Study of Liver Diseases.
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MeSH Terms
Bacterial Translocation / physiology*
Bacteroides fragilis / physiology
Bifidobacterium / physiology
Carbon Tetrachloride / adverse effects
Cecum / microbiology
Disease Models, Animal
Enterococcus faecalis / physiology
Escherichia coli / physiology
Hypertension, Portal / etiology,  physiopathology
Ileum / microbiology
Intestines / microbiology*
Ligation / adverse effects
Liver Cirrhosis / chemically induced,  metabolism*,  pathology*
Paneth Cells / metabolism*,  pathology
Portal Vein / physiopathology
Protein Precursors / metabolism*
Rats, Inbred Strains
beta-Defensins / metabolism*
Reg. No./Substance:
0/Protein Precursors; 0/beta-Defensins; 120668-29-3/cryptdin; CL2T97X0V0/Carbon Tetrachloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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