Document Detail

Intestinal anti-spasmodic effect of a phytodrug of Psidium guajava folia in the treatment of acute diarrheic disease.
MedLine Citation:
PMID:  12413703     Owner:  NLM     Status:  MEDLINE    
Ancestral medicinal use of guava (Psidium guajava L. Fam. Myrtaceae) is today supported by numerous biomedical studies concerning the properties of leaf extracts. However, insufficient clinical studies are reported on the use of this plant resource in the treatment of gastrointestinal ailments. The present work reports a randomized, double-blinded, clinical study performed to evaluate the safety and efficacy of a phytodrug (QG-5) developed from guava leaves, standardized in its content of quercetin and orally administered to a group of adult patients with acute diarrheic disease. Capsules containing 500 mg of the product were administered to 50 patients every 8 h during 3 days. Results obtained showed that the used guava product decreased the duration of abdominal pain in these patients.
Xavier Lozoya; Hortensia Reyes-Morales; Marco A Chávez-Soto; María del Carmen Martínez-García; Yolanda Soto-González; Svetlana V Doubova
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  83     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-04-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  19-24     Citation Subset:  IM    
Laboratory of Medicinal Plants at Research Unit of Neurological Diseases, Mexican Institute of Social Security (IMSS), Mexico City, Mexico.
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MeSH Terms
Acute Disease
Antidiarrheals / administration & dosage,  therapeutic use*
Diarrhea / drug therapy*,  pathology
Parasympatholytics / administration & dosage,  therapeutic use*
Plant Extracts / administration & dosage,  therapeutic use*
Plant Leaves
Treatment Outcome
Reg. No./Substance:
0/Antidiarrheals; 0/Parasympatholytics; 0/Plant Extracts

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