Document Detail

Intestinal absorption and lymphatic transport of fish oil (MaxEPA) in the rat.
MedLine Citation:
PMID:  2742878     Owner:  NLM     Status:  MEDLINE    
Adult male, chow-fed Sprague-Dawley rats were given intraduodenally a bolus of emulsion of 0.5 ml of fish oil (MaxEPA) or olive oil plus 0.5 ml of 20 mM sodium taurocholate. Intestinal lymph was collected from a cannula in the main intestinal lymph trunk for various times after oil administration. There was no difference in the absorption of either type of oil over 6 and 24 h, over which times about 40 and 70% of the administered dose was taken up. For MaxEPA, the flux of triacylglycerols remained at a basal level of 0.07 mumol/min for 30 min, after which it rose rapidly to a maximum of 0.87 mumol/min between 90 and 120 min. The flux was 0.4 mumol/min for the subsequent 4 h. After 30 min, the composition of the lymph triacylglycerols began to change to show the presence of large proportions of fatty acyl chains that were characteristic of fish oil, especially eicosapentaenoate (20:5(n-3] and docosahexaenoate (22:6(n-3]. The composition of the lymph remained fairly similar to that of the fish oil for up to 6 h, the last time point at which detailed analysis was done. The docosahexaenoate in the triacylglycerols of the fish oil was primarily in the sn-2 position of glycerol, whereas a more random distribution of eicosapentaenoate over all glycerol positions was found. The positional distribution of the acids in the lymph triacylglycerols was similar to that in the fish oil. There was no evidence of substantial chain elongation or shortening during absorption. The results indicate that fish oil is effectively absorbed from the rat intestine without substantial alteration in the acyl chains of the triacylglycerols.
G A Chernenko; J A Barrowman; K T Kean; G R Herzberg; K M Keough
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1004     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  95-102     Citation Subset:  IM    
Division of Gastroenterology, Memorial University of Newfoundland, St. John's, Canada.
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MeSH Terms
Biological Transport
Docosahexaenoic Acids*
Drug Combinations
Eicosapentaenoic Acid*
Fatty Acids / metabolism
Fatty Acids, Unsaturated / pharmacokinetics*
Fish Oils / pharmacokinetics*
Intestinal Absorption*
Lymph / metabolism*
Plant Oils / pharmacokinetics
Rats, Inbred Strains
Triglycerides / metabolism
Reg. No./Substance:
0/Drug Combinations; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 0/Maxepa; 0/Plant Oils; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids; 8001-25-0/olive oil

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