Document Detail


Intestinal absorption of long-chain fatty acids: evidence and uncertainties.
MedLine Citation:
PMID:  19280719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the two last decades, cloning of proteins responsible for trafficking and metabolic fate of long-chain fatty acids (LCFA) in gut has provided new insights on cellular and molecular mechanisms involved in fat absorption. To this systematic cloning period, functional genomics has succeeded in providing a new set of surprises. Disruption of several genes, thought to play a crucial role in LCFA absorption, did not lead to clear phenotypes. This observation raises the question of the real physiological role of lipid-binding proteins and lipid-metabolizing enzymes expressed in enterocytes. The goal of this review is to analyze present knowledge concerning the main steps of intestinal fat absorption from LCFA uptake to lipoprotein release and to assess their impact on health.
Authors:
Isabelle Niot; H?l?ne Poirier; Thi Thu Trang Tran; Philippe Besnard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Progress in lipid research     Volume:  48     ISSN:  1873-2194     ISO Abbreviation:  Prog. Lipid Res.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-11     Completed Date:  2010-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900832     Medline TA:  Prog Lipid Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-15     Citation Subset:  IM    
Affiliation:
Physiologie de la Nutrition, UMR Inserm U866, Ecole Nationale Sup?rieure de Biologie Appliqu?e ? la Nutrition et ? l'Alimentation, Universit? de Bourgogne, 1, Esplanade Erasme, F-21000 Dijon, France. niot@u-bourgogne.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane / metabolism
Chylomicrons / metabolism
Dietary Fats / pharmacokinetics
Enterocytes / metabolism
Fatty Acid-Binding Proteins / physiology
Fatty Acids / pharmacokinetics*
Humans
Hypertriglyceridemia / physiopathology
Intestinal Absorption / physiology*
Intestine, Small / metabolism,  physiology
Lipid Metabolism / physiology
Mice
Chemical
Reg. No./Substance:
0/Chylomicrons; 0/Dietary Fats; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids

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