| Intestinal absorption of long-chain fatty acids: evidence and uncertainties. | |
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MedLine Citation:
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PMID: 19280719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over the two last decades, cloning of proteins responsible for trafficking and metabolic fate of long-chain fatty acids (LCFA) in gut has provided new insights on cellular and molecular mechanisms involved in fat absorption. To this systematic cloning period, functional genomics has succeeded in providing a new set of surprises. Disruption of several genes, thought to play a crucial role in LCFA absorption, did not lead to clear phenotypes. This observation raises the question of the real physiological role of lipid-binding proteins and lipid-metabolizing enzymes expressed in enterocytes. The goal of this review is to analyze present knowledge concerning the main steps of intestinal fat absorption from LCFA uptake to lipoprotein release and to assess their impact on health. |
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Authors:
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Isabelle Niot; H?l?ne Poirier; Thi Thu Trang Tran; Philippe Besnard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Progress in lipid research Volume: 48 ISSN: 1873-2194 ISO Abbreviation: Prog. Lipid Res. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-11 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7900832 Medline TA: Prog Lipid Res Country: England |
Other Details:
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Languages: eng Pagination: 101-15 Citation Subset: IM |
Affiliation:
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Physiologie de la Nutrition, UMR Inserm U866, Ecole Nationale Sup?rieure de Biologie Appliqu?e ? la Nutrition et ? l'Alimentation, Universit? de Bourgogne, 1, Esplanade Erasme, F-21000 Dijon, France. niot@u-bourgogne.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane / metabolism Chylomicrons / metabolism Dietary Fats / pharmacokinetics Enterocytes / metabolism Fatty Acid-Binding Proteins / physiology Fatty Acids / pharmacokinetics* Humans Hypertriglyceridemia / physiopathology Intestinal Absorption / physiology* Intestine, Small / metabolism, physiology Lipid Metabolism / physiology Mice |
| Chemical | |
Reg. No./Substance:
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0/Chylomicrons; 0/Dietary Fats; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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