Document Detail

Intestinal absorption of free oleic acid in the unanesthetized rat: evidence for a saturable component?
MedLine Citation:
PMID:  6498625     Owner:  NLM     Status:  MEDLINE    
The intestinal absorption of free oleic acid at low intraluminal concentrations and the influence of luminal factors on its absorption were studied in the unanesthetized rat. The relationship between oleic acid concentration (30-2500 microM) and its rate of absorptions fitted best to a rectangular hyperbola (y = x/(2.19 + 0.0015x), r = 0.94). Oleic acid's rate of absorption increased as the hydrogen ion and sodium taurocholate concentrations were increased or as the thickness and resistance of the unstirred water layer were diminished or following the addition of lysolecithin. The additions of the artificial detergent Tween-80, or lecithin and linoleic, linolenic and arachidonic acids to the perfusate decreased oleic acid's rate of absorption. It was concluded that oleic acid absorption in this range of concentrations displays apparent saturation kinetics which are due to unstirred layer effects, limited aqueous solubility of oleic acid and possible saturation of cytosol fatty acid binding proteins. Factors which increase oleic acid's protonated concentration or diminish the unstirred layer resistance, enhance its absorption rate, while factors which enhance its micellar solubility or interfere with its transfer out of the cell membrane decrease its overall rate of absorption.
D Hollander; S L Chow; V D Dadufalza
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  62     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1985-01-14     Completed Date:  1985-01-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1136-40     Citation Subset:  IM    
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MeSH Terms
Carrier Proteins / physiology
Dose-Response Relationship, Drug
Fatty Acid-Binding Proteins
Fatty Acids / pharmacology
Hydrogen-Ion Concentration
Intestinal Absorption*
Neoplasm Proteins*
Nerve Tissue Proteins*
Oleic Acid
Oleic Acids / metabolism*
Phosphatidylcholines / pharmacology
Rats, Inbred Strains
Surface-Active Agents / pharmacology
Grant Support
Reg. No./Substance:
0/Carrier Proteins; 0/Fabp7 protein, rat; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids; 0/Neoplasm Proteins; 0/Nerve Tissue Proteins; 0/Oleic Acids; 0/Phosphatidylcholines; 0/Surface-Active Agents; 112-80-1/Oleic Acid; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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