Document Detail


Intestinal absorption during rest and exercise: implications for formulating an oral rehydration solution (ORS). Proceedings of a roundtable discussion. April 21-22, 1993.
MedLine Citation:
PMID:  8183089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Formulation of oral rehydration solutions (ORS) is reviewed in the context of methods for measuring absorption of water and component substrates, transport mechanisms of substrates and water, requirements of the athlete, and effects of exercise on absorption. The triple lumen tube intubation perfusion method is the optimal technique for obtaining absorption data from the human small intestine during rest and exercise. Factors that must be considered when interpreting absorption data obtained by this technique include the role of the mixing segment in altering composition of the infused solution, defining optimal segment length, effects of ORS osmolality, and absorption of "nonabsorbed" indicators. Absorption data are applicable only to the test segment and may lack relevance to ORS transport proximal and distal to the test segment. Absorption rate of an ORS measured by perfusion may not correlate with absorption rate following ingestion. Transport of water, electrolytes, carbohydrates, and other solutes including glutamine and amino acids is considered in relation to ORS formulation. Factors affecting absorption of an ORS including the unstirred layer, motility, intestinal blood flow, and maximal absorptive capacity of the alimentary tract are considered. Exercise per se at 30-70% VO2max for 60-90 min probably has minimal effects in limiting absorption of an ORS. Consideration relevant to supplying needs of the athlete during prolonged exercise in relation for ORS formulation are discussed.
Authors:
H P Schedl; R J Maughan; C V Gisolfi
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Publication Detail:
Type:  Congresses; Review    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  26     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-06-15     Completed Date:  1994-06-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  267-80     Citation Subset:  IM; S    
Affiliation:
Department of Exercise Science, University of Iowa, Iowa City 52242.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Body Water / metabolism
Exercise / physiology*
Gastrointestinal Motility
Humans
Intestinal Absorption*
Rehydration Solutions* / metabolism
Chemical
Reg. No./Substance:
0/Rehydration Solutions

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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