| Intestinal absorption of bile salts: immature development in the neonate. | |
| | |
MedLine Citation:
|
PMID: 423038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The intestinal absorption of sodium taurocholate was studied in fetuses, neonates, infants, children, and adults. Absorption rates were measured in vitro in everted rings of jejunum and ileum. Mucosal accumulation of 3H-taurocholate against a concentration gradient was consistently demonstrated in rings of ileum from adults, children, and infants older than 8 months, whereas fetal and neonatal ileal mucosal concentrations were not significantly above those in the incubation medium after exposure of the mucosa to 0.003, 0.03, and 0.3 mM taurocholate. There were no significant differences in mucosal uptake of taurocholate by perinatal jejunal and ileal rings. Incubations of mucosa from older infants, children, and adults in 0.3 mM taurocholate exhibited saturation phenomena. It is concluded that the ileal mechanism for active transport of taurocholate is undeveloped in the fetus and newborn infant. It is probable that the enterohepatic circulation of bile salt during the perinatal period is limited to that fraction of bile salt absorbed passively. The results suggest that losses of bile salt from the immature intestine may contribute to the steatorrhea and so-called diarrhea of newborn infants. |
| | |
Authors:
|
R C de Belle; V Vaupshas; B B Vitullo; L R Haber; E Shaffer; G G Mackie; H Owen; J M Little; R Lester |
Related Documents
:
|
8320528 - A case of quinsy in a fifteen-month old child. 15005968 - Kawasaki disease in thai infants compared with older children. 1167378 - Digestibility of starches in infants and children. 2669648 - Evaluation of prostacyclin analogue op-41483 as an adjunct to crystalloid cardioplegia ... 7843498 - Separation and depression in infant gorillas. 19943708 - Bacterial meningitis: epidemiology, pathogenesis and management update. |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: The Journal of pediatrics Volume: 94 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1979 Mar |
Date Detail:
|
Created Date: 1979-05-26 Completed Date: 1979-05-26 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 472-6 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Child Child, Preschool Fetus Humans Ileum / metabolism* Infant Infant, Newborn* Intestinal Absorption* Jejunum / metabolism Middle Aged Taurocholic Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
|
81-24-3/Taurocholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum concentrations of 25-hydroxyvitamin D in rickets of extremely premature infants.
Next Document: Reverse tri-iodothyronine to tri-iodothyronine ratio and gestational age.