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Intestinal spirochetosis mimicking inflammatory bowel disease in children.
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PMID:  23066991     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intestinal spirochetosis is an unusual infection in children and its clinical significance in humans is uncertain. The presence of these microorganisms in humans is well-known since the late 1800's and was first described in 1967 by Harland and Lee by electron microscopy.
CASE PRESENTATION: This article reports the findings of one pediatric case, review of the current literature, and an overview of therapeutic options.
CONCLUSION: A high degree of suspicion is required in cases presenting with abdominal pain, chronic diarrhoea and/or hematochezia associated with a normal endoscopic examination, thus emphasizing the importance of multiple biopsies throughout the colon.
Rossana Helbling; Maria-Chiara Osterheld; Bernard Vaudaux; Katia Jaton; Andreas Nydegger
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2012-10-16
Journal Detail:
Title:  BMC pediatrics     Volume:  12     ISSN:  1471-2431     ISO Abbreviation:  BMC Pediatr     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-25     Completed Date:  2013-04-01     Revised Date:  2013-07-11    
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Nlm Unique ID:  100967804     Medline TA:  BMC Pediatr     Country:  England    
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Languages:  eng     Pagination:  163     Citation Subset:  IM    
Pediatric Gastroenterology Unit, Department of Pediatrics, University of Lausanne, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland.
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MeSH Terms
Diagnosis, Differential
Inflammatory Bowel Diseases / diagnosis*
Intestinal Diseases / diagnosis*,  microbiology*
Spirochaetales Infections / diagnosis*

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Journal ID (nlm-ta): BMC Pediatr
Journal ID (iso-abbrev): BMC Pediatr
ISSN: 1471-2431
Publisher: BioMed Central
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Copyright ©2012 Helbling et al.; licensee BioMed Central Ltd.
Received Day: 6 Month: 7 Year: 2012
Accepted Day: 8 Month: 10 Year: 2012
collection publication date: Year: 2012
Electronic publication date: Day: 16 Month: 10 Year: 2012
Volume: 12First Page: 163 Last Page: 163
PubMed Id: 23066991
ID: 3480841
Publisher Id: 1471-2431-12-163
DOI: 10.1186/1471-2431-12-163

Intestinal Spirochetosis mimicking inflammatory bowel disease in children
Rossana Helbling1 Email:
Maria-Chiara Osterheld2 Email:
Bernard Vaudaux3 Email:
Katia Jaton4 Email:
Andreas Nydegger1 Email:
1Pediatric Gastroenterology Unit, Department of Pediatrics, University of Lausanne, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland
2Institute of Pathology, University of Lausanne, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 48, CH-1011, Lausanne, Switzerland
3Pediatric Infectious Disease Unit, Department of Pediatrics, University of Lausanne, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, CH-1011, Lausanne, Switzerland
4Institute of Microbiology, University of Lausanne, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 48, CH-1011, Lausanne, Switzerland


Spirochetes are well-known pathogens in veterinary medicine. They are associated with diarrheal illness, malnutrition and failure to thrive in a wide range of animals (swine, poultry, dogs, cats, opossum, non-human primates and guinea pigs) causing important economic losses [1].

The presence of intestinal spirochetes in human faeces has been recognized in the late 1800’s [2]. The term intestinal spirochetosis was coined in 1967 by Harland and Lee who recognized spirochetes adherent to the cellular membrane of apical cells in the colonic epithelium [3]. This histological appearance is considered to be the hallmark of this infection.

The clinical significance of intestinal spirochetes in humans remains highly debated. Indeed, it is still unclear whether the finding of microorganisms coating the intestinal mucosal membrane is simply the reflection of a colonization process or the histological aspect of a disease [4].

Case presentation

A 13 year-old boy presented to our paediatric gastroenterology outpatient clinic with a one month history of blood-stained diarrhoea, associated with urgency, weight loss of 1.5kg and asthenia. He had no complaint of abdominal pain, fever or anorexia. The onset of symptoms coincided with the end of a 4-day history of acute gastroenteritis.

His past medical history revealed a recurrent aphthous stomatitis, and his family history was positive for celiac disease (one maternal cousin), irritable bowel syndrome (one paternal uncle) and bowel cancer (paternal grandfather). His growth parameters were normal and the physical examination revealed palpable stool masses in the left lower abdomen. Based on the clinical presentation, the differential diagnosis included inflammatory bowel disease, celiac disease, infectious colitis and intestinal polyp. Laboratory investigations showed no biological markers for inflammation (normal full blood count, ESR: 5mm/h and CRP: 0.28mg/l) or celiac disease. Fecal calprotectin was not measured. Stool cultures for conventional enteric pathogens (Salmonella, Shigella Campylobacter) were negative. Upper and lower endoscopy revealed mucosal oedema in the sigmoid and rectum, which was probably due to the required bowel preparation for colonoscopy. Histological examination on conventional hematoxylin and eosin stain of the colonic biopsy specimens revealed a fuzzy band on the surface of the enterocytes. This finding was highly suggestive of intestinal spirochetosis (Figure 1). Interestingly, no specific inflammatory reaction or lesions were observed. The diagnosis of intestinal spirochetosis was confirmed by Fluorescence in situ hybridization (FISH), confirming the presence of Brachyspira aalborgi (Figure 2).

On the assumption that most intestinal spirochetes (obtained from veterinary specimens) are susceptible to amoxicillin, the patient was initially treated with this antibiotic (30mg/kg/day, divided into 3 doses) during 14 days, with subsequent cessation of rectal bleeding but persistent mucous diarrhoea. Additional treatment with metronidazole (30mg/kg/day, divided into 3 doses) for 10 days resulted in complete resolution of symptoms, therefore, no follow-up endoscopy was performed.


A Medline search was performed for all studies published from 1993 to December 2011 using the Medical Subject Heading and keywords: “intestinal spirochetosis” and “all child (0–18 years)”. Articles in any other language than English have been excluded. All studies retrieved were considered and data from relevant’ ones were presented in Table 1 and discussed in the text.


To the best of our knowledge, there were 8 articles describing a total of 25 paediatric cases of intestinal spirochetosis [5-12]. Three patients presented spirochetes on histopathological examination of a resected appendix without endoscopy. Sex distribution was similar (13 girls, 12 boys) with a median age of 9.5 years (range: 2–17 years). Patients mainly presented with abdominal pain, diarrhoea and rectal bleeding with, apart from aspecific signs of mild inflammation, normal endoscopic findings. Table 1 summarizes those 25 patients with respect to their age, symptoms, endoscopic and histological findings and treatment. Many patients had more than one treatment due to persistence of symptoms, although metronidazole seemed to be the favourite therapeutic agent. Two out of 5 patients improved without treatment and the overall outcome was favourable in 17 patients (68%).


Adhesion of spirochetes to the brush border mucosa resulting in its thickening as seen on light microscopy can be observed worldwide in both children and adults [1]. Diagnosis is usually made by histopathology.

Spirochetes are currently divided into three phylogenetic groups: Spirochaetaceae including Borrelia, Spirochaeta, Spironema and Treponema; Leptospiraceae including Leptonema and Leptospira; and finally Brachyspiraceae containing the intestinal spirochetes of Brachyspira (Serpulina)[1]. Brachyspira aalborgi (B. aalborgi) and Brachyspira pilosicoli (B. pilosicoli), the two members of Brachyspiraceae family, are both described in humans and are considered as cause of human intestinal spirochetosis [13]. The anaerobic weakly β-haemolytic intestinal spirochete B. aalborgi, was first isolated in 1982 in the stool of a patient from Denmark [14], whereas B. pilosicoli is responsible for colitis and typhlytis in pigs, poultry and other species, acting more as zoonotic agent [15]. Since 1997, Brachyspira spp. have been included in the list of human enteropathogenic bacteria [16]. These two spirochetes are slow growing fastidious anaerobes and require specific media, with estimated growth times of 6 days for B. pilosicoli and up to 2 weeks for B.aalborgi[17]. Morphologically, they are coiled Gram-negative bacilli and are mobile in liquid environment due to the presence of flagella. Generally they are considered non invasive microorganisms but systemic spread of B.pilosicoli has been documented by culture of blood specimens obtained from critically ill patients [18]. Concomitant infection by B.aalborgi and B.pilosicoli is described but rare [19]. These spirochetes are susceptible to different antibiotics, such as metronidazole, meropenem, chloramphenicol, ceftriaxone and tetracycline, whereas a 60% resistance rate to ciprofloxacine has been observed [20]. Little is known about the way of transmission, but it seems likely to occur by faecal-oral route (contaminated water, colonized/infected faeces) [19]. Due to the higher prevalence in homosexual men, sexual transmission has been suggested as well [21]. Possible co-infection with others microorganisms like Helicobacter pylori, Enterobius vermicularis, Shigella flexneri, Neisseria gonorrhoeae, Entamoeba histolytica, Blastocystis hominis, and Ascaris is possible, rendering clinical significance difficult [2].

The prevalence varies considerably in geography and immune condition. In developed countries for example ranges between 1.1-5% can be observed, with an increase in homosexual men and HIV positive patients [1]. In a recent study from Japan the incidence of human intestinal spirochetosis in patients aged from 35 to 75 years was 0.4% and therefore lower than in Western countries [22]. The paucity of epidemiologic data is probably due to several reasons: firstly: the endoscopist not always takes routine multiple biopsies in healthy looking mucosa; secondly: the pathologist actively has to look for spirochetes and can easily miss them if not familiar with its appearance and thirdly: it is not a routine diagnosis by microbiologist either [11].

In most cases, intestinal spirochetosis is asymptomatic and presents as accidental findings during a screening colonoscopy for other reasons [23]. However, infected children usually complain of persistent diarrhoea, rectal bleeding, constipation, abdominal pain, weight loss, failure to thrive, nausea and lack of appetite [24]. The severity of disease can vary from asymptomatic colonisation to invasive and rapidly fatal progression [25], but there appears to be no correlation with degree of immunodeficiency in HIV positive patient and the extent of disease [1]. Due to this unspecific presentation, differential diagnosis should include inflammatory bowel disease, infectious, ischemic or pseudomembranous colitis and rectocolic carcinoma [24]. Colonic involvement is documented from distal to proximal, including rectum and appendix [26]. Mucosal appearance on endoscopy is not helpful in making the diagnosis, as it can be normal, polypoid, and erythematous, or just show unspecific lesions [27]. In a large Australian case series of 113 adult patients presenting with intestinal spirochetosis, 90 percent of colorectal specimens showed no morphological alterations, whereas the remaining cases had other possible causes for inflammation [23]. Histological appearance of a diffuse blue-fringe (better seen in hematoxylin-eosin or a silver stain), 3-6μm thick, along the border of intestinal epithelial layer, referred to as the « false brush border » is highly suggestive [1]. The surrounding cytostructure may show inflammation with slight oedema, infiltrate of monocytes, lymphocytes, plasma cells and neutrophils in the lamina propria, as well as elongated and hyperplastic crypts [28]. On electron microscopy, spirochetes are attached perpendicularly to the epithelial membrane of the enterocytes and the microvilli appear shortened or depleted [3]. Analysis of specimens from infected individuals even though rare has shown spirochetal invasion of colonic epithelial cells, macrophages, goblet cells and Schwann cells [29]. Histologically it is not possible to distinguish B.pilosicoli from B.aalborgi, therefore genetic methods have been developed in order to identify Brachyspira species from stool or tissue samples. Fluorescent in situ hybridization using oligonucleotide probes targeting 16S or 23S rRNA of B. aalborgi and B. pilosicoli allow visualisation and identification of this microorganism [28].

Treatment strategies have been proposed for intestinal spirochetosis eradication, including macrolids and clindamycin, but metronidazole seems to be the drug of choice, with a dose regimen of 500mg 3 times a day for 10 days in adults and 15mg per kg bodyweight 3 times per day for 5 days in children [19]. At the moment, there is lack of evidence regarding the most effective antibiotic agent as treatment response is variable and sometimes even ineffective supporting the hypothesis that these microorganisms are harmless commensals in humans, rendering specific treatment questionable [1]. Spontaneous recovery has been described after a prolonged period for up to 8 months [8].


Intestinal spirochetosis may be more frequent than suspected and clinicians should take into account this disease, especially in case of persistent diarrhoea without any other reason. Diagnosis can only be made by an experienced pathologist and microbiologist and requires a lower endoscopy with multiple biopsies throughout the colon.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

RH drafted the manuscript and collected data related to the subject; BV was involved in revising critically the manuscript and helped to draft the manuscript. AN participated in the design of the manuscript and the coordination. All authors read and approved the final manuscript.

Pre-publication history

The pre-publication history for this paper can be accessed here:


Written consent was obtained from the patient’s parents for publication of this case report.

Author details

1Pediatric Gastroenterology Unit, Department of Pediatrics, University of Lausanne, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland. 2Institute of Pathology, University of Lausanne, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 48, CH-1011 Lausanne, Switzerland. 3Pediatric Infectious Disease Unit, Department of Pediatrics, University of Lausanne, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland.4Institute of Microbiology, University of Lausanne, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 48, CH-1011 Lausanne, Switzerland.

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[Figure ID: F1]
Figure 1 

A: Hematoxylin and eosin stain of colon biopsy specimen showing multitudes of organisms along apical border of enterocytes, resembling a “false brush border” (H&E, orig. mag. x10).B: Colonic mucosa with thick hematoxyphilic fringe on the brush border of the luminal surface (H&E, orig. mag. X40).

[Figure ID: F2]
Figure 2 

Visualisation and identification of Brachyspira spp. in a colon biopsy specimen by FISH (white arrows). Blue dots stand for counterstained cell nuclei.

[TableWrap ID: T1] Table 1 

Description of 25 cases of pediatric intestinal spirochetosis (IS)

Ref. Age (y) Sex Signs and Symptoms Endoscopic findings Histologic findings Treatment Comments
Rectal bleeding, abdominal pain, pruritus ani
IS and mild inflammation
Intermittent bloody diarrhoea
Distal colitis
IS and mild to moderate infiltration with inflammatory cells
Mebendazole (Ascaris in stool)
Recurrent fever, abdominal pain, joint pain, mouth and penile ulcers
IS and mild patchy inflammation
No treatment
No follow-up information
Periumbilical pain, frequent bloody stools, urgency, poor appetite and weight loss
Mild rectal granularity
1) Metronidazole
Persistence of diarrhea; eradication on endoscopicfollow-up at 6 months
2) Neomycine
Acute abdominal pain, vomiting and fever
Not done
IS in resected appendix
No treatment
Intermittent vomiting, diarrhoea, weight loss, headaches and fatigue
IS and mild focal colitis
Metronidazole and Amoxicillin (7 days)
Recurrent abdominal pain
IS and mild focal cryptitis in the caecum
1) Penicillin V and Metronidazole (7 days)
Persistence of symptoms and IS; after second course of Metronidazole eradication and improvement
2) Metrodidazole (800mg 3x/d for 7 days)
Recurrent colicky right upper quadrant pain
Metronidazole and Amoxicillin (10 days)
Intermittent diarrhoea and rectal bleeding
Metronidazole and Amoxicillin (10 days)
Abdominal pain, diarrhoea and rectal bleeding
Rectal oedema and enterobiasis
Erythromycin (40mg/kg/d for 10 days)
Rectal bleeding ceased but abdominal pain recurred, no follow-up
Abdominal pain and diarrhoea
Slight proctitis
Doxycycline (200mg day1, then 100mg/d for 8 days )
Persistence of abdominal pain despite endoscopic eradication
Mucus and bloody stools
Proctitis, juvenile polyp
Clarithromycin (50mg/kg/d for 10 days)
Diarrhoea and rectal bleeding
Rectal hyperaemic membranes
Abdominal pain, nausea and weight loss
Slight inflammation of rectum
IS and HP- positive gastritis
1) Clarithromycin and Amoxicillin
Persistence of IS, eradication after Clarithromycin and Metronidazole
2) Clarithromycin and Metronidazole (500mg 2x/d and 400mg 3x/d 7 days)
Recurrent abdominal pain
Juvenile polyp
IS and low-grade chronic inflammation
1) Penicillin V
Improvement after Erythromycin
2) Erythromycin (40-50mg/kg/d for 10 days)
Abdominal pain and rectal bleeding
Clarithromycin (500mg 2x/d for 14 days)
Improvement but persistence of rectal bleeding; absence of IS on follow-up rectoscopy
Abdominal pain
Metronidazole (400mg 3x/d for 10 days)
No improvement; absence of IS on follow-up colonoscopy
Recurrent abdominal pain, diarrhea and rectal bleeding
Mild erythema of rectal mucosa
IS and hypereosinophilia
Erythromycin (40mg/kg/d for 10 days)
Rectal bleeding, diarrhea, tenesmus, flatulence and weight loss
IS and mild epithelial reactive changes
No treatment
Abdominal discomfort, rectal bleeding and weight loss
Mucosal erosions, hyperemia, 2 juvenile polyps
IS and inflammatory infiltrate
Intermittent abdominal pain and rectal bleeding
1)Metronidazole (250mg 3x/d)
No improvement, additional course of Metronidazole and Vancomycin with persistence of IS, no follow-up information
2) Metronidazole (1000mg/d for 2 months and 750 mg/d for 14 days)
3) Vancomycin (7 days)
Stomach cramps, rectal bleeding, intermittent diarrhea, rectal prolapse
Metronidazole (250mg 2x/d)
Improvement, but alternating constipation with watery diarrhea and rectal prolapse
Recurrent abdominal pain, nausea, vomiting
IS and mild eosinophilic inflammatory infiltrate
No treatment
No follow-up information
Right lower quadrant pain
Not done
Appendicitis and IS in resected appendix
Cefoxitin (30mg/kg/dose, 4 doses)
No follow-up information
  10 M Periumbilical and epigastric pain, nausea, fever Not done Appendicitis and IS in resected appendix No treatment No follow-up information

Article Categories:
  • Case Report

Keywords: Intestinal spirochetosis, Brachyspira aalborgi, Brachyspira pilosicoli, Inflammatory bowel disease.

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