Document Detail


Intestinal STC-1 cells respond to five basic taste stimuli.
MedLine Citation:
PMID:  18007200     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
STC-1 cells have been established as an enteroendocrine cell line from the small intestine. By monitoring the level of intracellular Ca using a calcium-imaging technique, cellular responses of intestinal STC-1 cells to compounds of five basic tastants were investigated. Although this cell line was known to respond to bitter compounds, we found that compounds of the other four basic tastants also stimulate STC-1 cells. When solutions containing glutamate, sucrose, HCl, or NaCl were applied, the intracellular Ca concentration in STC-1 cells significantly increased. We thus demonstrated that the gastrointestinal system can sense all five basic taste stimuli, and that STC-1 cells emerge as a new cell model for studying the molecular mechanism of signaling pathways of the five basic tastants.
Authors:
Osamu Saitoh; Atsushi Hirano; Yui Nishimura
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  18     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  1991-5     Citation Subset:  IM    
Affiliation:
Department of Bio-Science, Faculty of Bio-Science, Nagahama Institute of Bio-Science and Technology, Nagahama-shi, Shiga, Japan. o_saito@nagahama-i-bio.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aniline Compounds
Calcium / metabolism*
Calcium Signaling / drug effects,  physiology*
Cell Line
Enteroendocrine Cells / drug effects,  metabolism*
Glutamic Acid / metabolism,  pharmacology
Humans
Hydrochloric Acid / metabolism,  pharmacology
Indicators and Reagents
Intestines / cytology,  metabolism*
Models, Biological
Signal Transduction / drug effects,  physiology
Sodium Chloride / metabolism,  pharmacology
Sucrose / metabolism,  pharmacology
Taste / drug effects,  physiology*
Taste Buds / physiology
Xanthenes
Chemical
Reg. No./Substance:
0/Aniline Compounds; 0/Fluo 4; 0/Indicators and Reagents; 0/Xanthenes; 56-86-0/Glutamic Acid; 57-50-1/Sucrose; 7440-70-2/Calcium; 7647-01-0/Hydrochloric Acid; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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