Document Detail

Intestinal protozoa infections among patients with ulcerative colitis: prevalence and impact on clinical disease course.
MedLine Citation:
PMID:  20145404     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Epidemiological and microbiologic studies suggest that enteropathogenic microorganisms play a substantial role in the clinical initiation and relapses of inflammatory bowel disease. AIM: To explore the prevalence of intestinal protozoa in patients with ulcerative colitis (UC) and its impact on clinical disease course. METHODS: A total of 215 patients with definitive diagnosis of UC were studied. Fresh feces samples taken from all UC patients were examined immediately using trichrome-staining methods. RESULTS: A total of 103 female and 112 male UC patients were analyzed. The mean age at diagnosis was 30.5 +/- 10.8 years. The prevalence of overall parasitic infections was 24% and distributed as follows: Blastocystis hominis in 22 patients (10%), Endolimax nana in 19 cases (9%), and Entamoebahistolytica in 11 cases (5%). A significantly increased frequency of protozoa infection was found in those patients with persistent activity and intermittent activity as compared to active than inactive group (p = 1 x 10(-7), OR 13.05, 95% CI 4.28-42.56, and p = 0.003, OR 1.42-14.47, respectively). Interestingly, this association remained significant when we compared the persistent activity group versus intermittent activity group (p = 0.003, OR 2.97, 95% CI 1.35-6.59). Subgroup analysis showed no association between protozoa infection (E. histolytica, B. hominis, and E. nana) and other clinical variables such as gender, extent of disease, extraintestinal complications, medical treatment and grade of disease activity. CONCLUSION: The prevalence of intestinal protozoa infections in Mexican UC patients was 24% and these microorganisms could be a contributing cause of persistent activity despite medical treatment in our population.
Jesús K Yamamoto-Furusho; Emma Torijano-Carrera
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Publication Detail:
Type:  Journal Article     Date:  2010-02-09
Journal Detail:
Title:  Digestion     Volume:  82     ISSN:  1421-9867     ISO Abbreviation:  Digestion     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  18-23     Citation Subset:  IM    
Copyright Information:
2010 S. Karger AG, Basel.
Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
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MeSH Terms
Amebiasis / epidemiology*,  parasitology
Blastocystis Infections / epidemiology*,  parasitology
Blastocystis hominis / isolation & purification
Chi-Square Distribution
Colitis, Ulcerative / epidemiology,  parasitology*
Disease Progression
Dysentery, Amebic / epidemiology,  parasitology
Endolimax / isolation & purification
Entamoeba histolytica / isolation & purification
Feces / parasitology
Mexico / epidemiology
Middle Aged

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