Document Detail


Intestinal microbiota of infants with colic: development and specific signatures.
MedLine Citation:
PMID:  23319531     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To provide a comprehensive analysis of the fecal microbiota in infants with colic, as compared with control infants, during their first 100 days of life.
METHODS: Microbial DNA of >200 samples from 12 infants with colic and 12 age-matched control infants was extracted and hybridized to a phylogenetic microarray.
RESULTS: Microbiota diversity gradually increased after birth only in the control group; moreover, in the first weeks, the diversity of the colic group was significantly lower than that of the control group. The stability of the successive samples also appeared to be significantly lower in the infants with colic for the first weeks. Further analyses revealed which bacterial groups were responsible for colic-related differences in microbiota at age 1 or 2 weeks, the earliest ages with significant differences. Proteobacteria were significantly increased in infants with colic compared with control infants, with a relative abundance that was more than twofold. In contrast, bifidobacteria and lactobacilli were significantly reduced in infants with colic. Moreover, the colic phenotype correlated positively with specific groups of proteobacteria, including bacteria related to Escherichia, Klebsiella, Serratia, Vibrio, Yersinia, and Pseudomonas, but negatively with bacteria belonging to the Bacteroidetes and Firmicutes phyla, the latter of which includes some lactobacilli and canonical groups known to produce butyrate and lactate.
CONCLUSIONS: The results indicate the presence of microbial signatures in the first weeks of life in infants who later develop colic. These microbial signatures may be used to understand the excessive crying. The results offer opportunities for early diagnostics as well as for developing specific therapies.
Authors:
Carolina de Weerth; Susana Fuentes; Philippe Puylaert; Willem M de Vos
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-14
Journal Detail:
Title:  Pediatrics     Volume:  131     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-04-11     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e550-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Bacterial Load
Bacteroidetes / genetics
Colic / epidemiology,  genetics,  microbiology*
Cross-Sectional Studies
DNA Barcoding, Taxonomic
Feces / microbiology
Female
Genetic Variation / genetics
Gram-Positive Bacteria / genetics
Humans
Infant
Infant, Newborn
Intestines / microbiology*
Male
Metagenome / genetics*
Oligonucleotide Array Sequence Analysis
Prospective Studies
Proteobacteria / genetics
Statistics as Topic
Transcriptome / genetics
Comments/Corrections
Comment In:
Gut Microbes. 2013 Sep-Oct;4(5):416-21   [PMID:  23941920 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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