Document Detail

Intestinal B cell-activating factor: an indicator of non-IgE-mediated hypersensitivity reactions to food?
MedLine Citation:
PMID:  20353497     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Medically confirmed hypersensitivity reactions to food are usually IgE-mediated. Non-IgE-mediated reactions are not only seldom recognized but also more difficult to diagnose.
AIM: To examine B cell-activating factor (BAFF) in serum and gut lavage fluid of patients with self-reported food hypersensitivity, and to study its relationship to atopic disease.
METHODS: Gut lavage fluid was obtained from 60 and serum from another 17 patients with self-reported food hypersensitivity. Twenty healthy volunteers served as controls, gut lavage fluid was obtained in all, serum from 11 of 20. The patients were divided into atopic and non-atopic subgroups. BAFF was measured by ELISA in both serum and gut lavage fluid.
RESULTS: B cell-activating factor levels in serum and gut lavage fluid were significantly higher in patients than in controls (P < 0.03 and P < 0.002 respectively). Non-atopic patients had significantly higher levels of BAFF in serum than both atopic patients (P < 0.05) and controls (P < 0.05). There was no significant correlation between serum levels of BAFF and IgE.
CONCLUSIONS: The results suggest that BAFF might be a new mediating mechanism in food hypersensitivity reactions. Significantly higher levels in non-atopic compared with atopic patients, and no correlation between BAFF and IgE, suggest that BAFF might be involved particularly in non-IgE-mediated reactions.
G Arslan Lied; K Lillestøl; J Valeur; A Berstad
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Publication Detail:
Type:  Journal Article     Date:  2010-03-26
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  32     ISSN:  1365-2036     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  66-73     Citation Subset:  IM    
Institute of Medicine, University of Bergen, Norway. <>
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MeSH Terms
B-Cell Activating Factor / immunology*,  physiology
Biological Markers / analysis
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Food Hypersensitivity / immunology*,  physiopathology
Gastrointestinal Tract / physiology
Hypersensitivity, Immediate / immunology*,  physiopathology
Middle Aged
Quality of Life
Statistics as Topic
Young Adult
Reg. No./Substance:
0/B-Cell Activating Factor; 0/Biological Markers

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