| Interweaving the cell cycle machinery with cell differentiation. | |
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MedLine Citation:
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PMID: 18000404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A comprehensive understanding of the mechanisms coupling cell cycle exit and differentiation is important for both cancer biology and tissue development. Cancer cells can arise from either stem/progenitor cells that fail to exit the cell cycle and differentiate, or from de-differentiated cells that have re-entered the cell cycle. Much of our current understanding of this coupling is based on observations made in transformed cell lines. These studies have shown that enforcing proliferation prevents differentiation and inducing growth arrest leads to differentiation; thus, one widely-held view is that changes in cell cycle regulators simply induces cell cycle exit, a pre-requisite for differentiation. However, recent evidence indicates that cell cycle regulators can affect differentiation in other ways as well. They can have a role establishing the new transcriptional program that accompanies differentiation--in its most radical form, the molecular mechanism of arrest might even be an integral component of the differentiation program. Additionally, the regulators or mechanisms that prevent the re-entry of cells into the proliferative cycle may not be those that induce exit from the cell cycle. Our goal in this perspective is to highlight examples from our laboratory that provided a broader understanding of the types of roles that cell cycle regulators play during differentiation, beginning with the phenotypes observed in mice. |
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Authors:
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Jeffrey P Miller; Nancy Yeh; Anxo Vidal; Andrew Koff |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2007-09-11 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 6 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-24 Completed Date: 2008-02-27 Revised Date: 2008-09-23 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 2932-8 Citation Subset: IM |
Affiliation:
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Program in Molecular Biology, Weill School of Medicine, Cornell University, New York, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle* Cell Cycle Proteins / physiology Cell Differentiation* Cell Proliferation Cell Transformation, Neoplastic Humans |
| Grant Support | |
ID/Acronym/Agency:
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CA89563/CA/NCI NIH HHS; CA96582/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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