Document Detail


Intervillous blood flow during caesarean section with prophylactic ephedrine and epidural anaesthesia.
MedLine Citation:
PMID:  6435379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We administered a 15 mg i.v. bolus of ephedrine at the commencement of epidural blockade to nine healthy parturients scheduled for elective caesarean section. Nine other patients did not receive prophylactic ephedrine before epidural anaesthesia (control group). Lactated Ringer solution, 30 ml/kg, was infused before and during blockade, and left uterine displacement was used to minimize aortocaval compression. A133Xe i.v. technique was used to measure intervillous blood flow (IBF) before and 20-25 min after epidural block. The mean arterial pressure (MAP) decreased after epidural blockade in the ephedrine group by 0.67 +/- 0.8 (mean +/- s.d.) kPa and by 1.20 +/- 1.1 (mean +/- s.d.) kPa in the control group. In spite of the decrease in MAP, IBF increased by 6% in patients receiving ephedrine (N.S.), whereas it decreased by 11% in the control group (N.S.). In the ephedrine group there was in this preliminary study a trend to increasing IBF during falling perfusion pressure (MAP). The results of this preliminary study suggest that ephedrine will not affect IBF, but to prevent maternal hypotension ephedrine should be used as an i.v. infusion instead of a bolus injection.
Authors:
A I Hollmén; R Jouppila; G A Albright; P Jouppila; H Vierola; A Koivula
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  28     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-11-01     Completed Date:  1984-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  396-400     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anesthesia, Epidural / adverse effects*
Anesthesia, Obstetrical*
Blood Glucose / metabolism
Carbon Dioxide / blood
Cesarean Section*
Ephedrine / therapeutic use*
Female
Humans
Hypotension / prevention & control
Oxygen Consumption
Placenta / blood supply*
Pregnancy
Regional Blood Flow / drug effects
Chemical
Reg. No./Substance:
0/Blood Glucose; 124-38-9/Carbon Dioxide; 299-42-3/Ephedrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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