Document Detail

Intervillous blood flow during caesarean section with prophylactic ephedrine and epidural anaesthesia.
MedLine Citation:
PMID:  6435379     Owner:  NLM     Status:  MEDLINE    
We administered a 15 mg i.v. bolus of ephedrine at the commencement of epidural blockade to nine healthy parturients scheduled for elective caesarean section. Nine other patients did not receive prophylactic ephedrine before epidural anaesthesia (control group). Lactated Ringer solution, 30 ml/kg, was infused before and during blockade, and left uterine displacement was used to minimize aortocaval compression. A133Xe i.v. technique was used to measure intervillous blood flow (IBF) before and 20-25 min after epidural block. The mean arterial pressure (MAP) decreased after epidural blockade in the ephedrine group by 0.67 +/- 0.8 (mean +/- s.d.) kPa and by 1.20 +/- 1.1 (mean +/- s.d.) kPa in the control group. In spite of the decrease in MAP, IBF increased by 6% in patients receiving ephedrine (N.S.), whereas it decreased by 11% in the control group (N.S.). In the ephedrine group there was in this preliminary study a trend to increasing IBF during falling perfusion pressure (MAP). The results of this preliminary study suggest that ephedrine will not affect IBF, but to prevent maternal hypotension ephedrine should be used as an i.v. infusion instead of a bolus injection.
A I Hollmén; R Jouppila; G A Albright; P Jouppila; H Vierola; A Koivula
Related Documents :
11475179 - Lack of intravenous lidocaine effects on hrv changes of tracheal intubation during indu...
19577409 - Bis response to tamponade and dobutamine in swine varies with hypnotic/opiate ratio.
8460809 - A comparison of propofol and methohexitone for dental chair anaesthesia in children.
11194979 - Clinical comparison of either small doses of fentanyl or remifentanil for blunting card...
1415969 - Thoracic electrical bioimpedance measurement of cardiac output and cardiovascular respo...
11473879 - The effect of large-dose intrathecal opioids on the autonomic nervous system.
16538979 - Amphotericin b-induced severe hypertension in a young patient: case report and review o...
15792179 - Anterior mitral basal 'stay' chords are essential for left ventricular geometry and fun...
7161009 - Changes in spontaneous ureteral peristalsis in experimental shock with and without admi...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  28     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-11-01     Completed Date:  1984-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  396-400     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthesia, Epidural / adverse effects*
Anesthesia, Obstetrical*
Blood Glucose / metabolism
Carbon Dioxide / blood
Cesarean Section*
Ephedrine / therapeutic use*
Hypotension / prevention & control
Oxygen Consumption
Placenta / blood supply*
Regional Blood Flow / drug effects
Reg. No./Substance:
0/Blood Glucose; 124-38-9/Carbon Dioxide; 299-42-3/Ephedrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Halothane dissolved in fat as an intravenous anaesthetic to rats.
Next Document:  Controlled ventilation using the Lack circuit with an injector device.