Document Detail

Interview with Suzanne Oparil, MD. Interview by Marvin Moser, MD.
MedLine Citation:
PMID:  15365278     Owner:  NLM     Status:  MEDLINE    
In this month's issue of The Journal of Clinical Hypertension, we highlight another hypertension icon. Dr. Suzanne Oparil is a clinical cardiologist who has been involved in the investigation of some of the fundamental mechanisms of vascular disease. Information derived from her studies has been used to develop specific treatments for hypertension. Dr. Oparil was one of those few women who attended medical school at a time when most of the students were males. She graduated at the top of her class at Columbia University College of Physicians and Surgeons and trained at Columbia and the Massachusetts General Hospital. She was on the faculty of the University of Chicago until 1977, when she transferred to become Professor of Medicine,Physiology, and Biophysics at the University of Alabama at Birmingham, where she has continued her research. Early in her career, Dr. Oparil observed that angiotensin-converting enzyme (ACE) was capable of generating a vasoconstrictor hormone, angiotensin II. Her work, along with that of investigators at the Massachusetts General Hospital and other institutions, led to the development of ACE inhibitors. Initially, Dr. Oparil's interest was focused on the pulmonary circulation. She identified endothelin as a major mediator of pulmonary hyper-tension and as a potent vasoconstrictor. In recent years, she has been investigating novel pathways by which estrogens protect against vascular injury. Her work has led to important clues about how female sex hormones protect blood vessels. Throughout her career as a basic scientist, Dr. Oparil has also maintained a clinical interest. She has been involved in numerous hypertension clinical trials with different medications. She served as President of the American Heart Association and was the first woman president of the American Federation of Medical Research. Dr. Oparil has always been an outspoken critic of those in medicine who speak to hear themselves heard. She has been a strong advocate of approaches to treatment that may not have been popular. Throughout her career, she has combined scientific judgment with stern clinical discipline. Her contributions to the understanding of hypertension have been significant.
Suzanne Oparil
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Publication Detail:
Type:  Interview    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  6     ISSN:  1524-6175     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-14     Completed Date:  2004-11-16     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-12     Citation Subset:  IM    
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Hypertension / prevention & control*
Research Design
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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