Document Detail


Interventricular delay measurement using equilibrium radionuclide angiography before resynchronization therapy should be performed outside the area of segmental wall motion abnormalities.
MedLine Citation:
PMID:  20936409     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: The aim of this study was to demonstrate that only mechanical dyssynchrony outside the area of segmental wall motion abnormalities (WMA) can be reduced by cardiac resynchronization therapy (CRT).
METHODS AND RESULTS: Included in the study were 28 consecutive patients with nonischaemic cardiomyopathy selected for CRT. Equilibrium radionuclide angiography (ERNA) was carried out before and after implantation of a multisite pacemaker. Patients were separated into two groups depending on the presence or absence of segmental WMA.
RESULTS: A reduction in QRS duration was observed in all patients after CRT. The interventricular delay (IVD) decreased significantly after CRT only in patients without WMA (homogeneous contraction, HG group; IVD 44 ± 11.4° vs. 17 ± 3.1°, p = 0.04). In contrast, no significant decrease was observed in patients with WMA (WMA group; IVD 51 ± 6° vs. 38 ± 6°, p NS). However, when dyssynchrony was considered outside the WMA area, a significant reduction in IVD was obtained, in the same range as in the HG group (IVD 32 ± 3° vs. 19 ± 3°, p = 0.04). In 9 of 15 patients (60%) with a reduction in IVD after CRT, the left ventricle ejection fraction (LVEF) increased by about +10%. In contrast, in 13 of 13 patients (100%) with no reduction in IVD, no modification of LVEF was obtained. In the presence of segmental WMA without significant delays outside the WMA area, no reduction in IVD was observed and LVEF did not increase (IVD 34 ± 5° before CRT vs. 37 ± 7° after CRT; LVEF 19 ± 4% before CRT vs. 22 ± 3% after CRT, p NS).
CONCLUSION: ERNA can be used to predict good mechanical resychronization (decrease in IVD) in patients after pacing. IVD has to be determined excluding the area of WMA in order to select patients who will show an increase in their left ventricle function after CRT.
Authors:
Maxime Courtehoux; Noura Zannad; Laurent Fauchier; Dominique Babuty; Veronique Eder
Related Documents :
7555479 - Impaired left ventricular diastolic function and vascular postischemic vasodilation ass...
19817519 - Prevalence and risk factors of myocardial remodeling in hemodialysis patients.
6217739 - Relation of electrocardiographic abnormalities and patterns of left ventricular hypertr...
16507109 - Echocardiographic assessment of subclinical left ventricular eccentric hypertrophy in a...
9686809 - The clinical picture and diagnosis of diphtheritic carditis in children.
14752489 - Assessment of regional left ventricular filling dynamics using color kinesis in patient...
22105019 - Preadmission beta-blockers are associated with decreased incidence of neurogenic stunne...
6989149 - Non-specific immunity in nephrotic syndrome.
4013729 - Alterations of auditory evoked potentials during the course of chloroquine treatment.
Publication Detail:
Type:  Journal Article     Date:  2010-10-09
Journal Detail:
Title:  European journal of nuclear medicine and molecular imaging     Volume:  38     ISSN:  1619-7089     ISO Abbreviation:  Eur. J. Nucl. Med. Mol. Imaging     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140988     Medline TA:  Eur J Nucl Med Mol Imaging     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  239-44     Citation Subset:  IM    
Affiliation:
Service EFMP CHU Trousseau, Route de Loches, 37044, Chambray les Tours cedex, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pathophysiologic correlates of (82)Rb biodistribution in cardiac PET/CT.
Next Document:  In vivo imaging of neuroinflammation in the rodent brain with [(11)C]SSR180575, a novel indoleacetam...